Treatment of wrinkles and strias with 4-hydroxyandrostenedione or a derivative thereof
The invention relates to the treatment of wrinkles in the face, wrinkles at open-necked regions, pregnancy strias, and stretched strias on the lower abdomen, thighs or buttocks with a steroidal aromatase inhibitor which also has 5-alpha reductase inhibitor activity which is 4-hydroxyandrostenedione or a derivative thereof.
1. A cosmetic treatment comprising the steps of:
identifying a subject suffering from a condition selected from the group consisting of wrinkles in the face, wrinkles at open-necked regions, pregnancy strias, and stretched strias on the lower abdomen, thighs or buttocks; and
administering a pharmaceutical composition comprising a steroidal aromatase inhibitor which also has 5-alpha-reductase inhibitor activity to said subject in an amount sufficient to alleviate at least one symptom of said condition wherein said steroidal aromatase inhibitor which also has 5-alpha reductase inhibitor activity is 4-hydroxyandrostenedione or a derivative thereof.
2. The cosmetic treatment method of claim 1 , wherein the steroidal aromatase inhibitor is 4-hydroxyandrost-4-ene-3,17-dione.
3. The cosmetic treatment method of claim 1 , wherein the pharmaceutical composition comprises between about 0.001 and about 5% by weight of said steroidal aromatase inhibitor.
4. The cosmetic treatment method of claim 2 , wherein the pharmaceutical composition comprises between about 0.001 and about 5% by weight of said steroidal aromatase inhibitor.
5. The cosmetic treatment method of claim 3 , wherein the pharmaceutical composition is topically administered.
6. The cosmetic treatment method of claim 4 , wherein the pharmaceutical composition is topically administered.
7. The cosmetic treatment method of claim 1 , wherein the steroidal aromatase inhibitor is 4-acetyoxy-4androstene-3,17-dione.