Stimulation of bone growth with thrombin peptide derivatives
View Patent ↗Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.
1. A method of stimulating bone growth in a subject at a site in need of bone growth and at which bone growth would not occur if left untreated, said method comprising the step of administering to the site a therapeutically effective amount of the peptide Ala-Gly-Tyr-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val-NH 2 (SEQ ID NO: 7).
2. The method of claim 1 wherein the agonist is administered in a pharmaceutical composition additionally comprising an implantable, biocompatible carrier.
3. The method of claim 2 wherein the implantable, biocompatible carrier is an osteoconductive matrix.
4. The method of claim 1 wherein the carrier comprises a polylactic acid/polyglycolic acid homopolymer or copolymer.
5. A method of stimulating bone growth in a subject at a site in need of a bone graft, said method comprising the step of administering to the site a therapeutically effective amount of the peptide Ala-Gly-Tyr-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val-NH 2 (SEQ ID NO: 7).
6. A method of stimulating bone growth in a subject at a segmental bone gap, a bone void or a non-union fracture comprising the step of administering to the bone gap, bone void or non-union fracture a therapeutically effective amount of the peptide Ala-Gly-Tyr-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val-NH 2 (SEQ ID NO: 7).