Mouse models of human prostate cancer
View Patent ↗The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
1. A female or castrated male immune deficient SCID mouse model having a human androgen-dependent cancer xenograft of locally advanced or metastatic prostate cancer; wherein the mouse model exhibits the transition from androgen-dependence to androgen-independence and recapitulates the development of primary tumors, micrometastais and formation of osteoblastic lesions characteristic of late stage prostate cancer; and wherein the xenograft is implanted subcutaneously, intraprostatically, or within a bone of the mouse.
2. The immune deficient SCID mouse model of claim 1 , wherein the xenograft is implanted subcutaneously.
3. The immune deficient SCID mouse model of claim 1 , wherein the xenograft is implanted intraprostatically.
4. The immune deficient SCID mouse model of claim 1 , wherein the xenograft is implanted within a bone of the mouse.
5. The immune deficient SCID mouse model of claim 1 , wherein the xenograft is from an explant selected from prostate, lymph node, lung, or bone tissue.
6. The immune deficient SCID mouse model of claim 1 , wherein the xenograft is a prostate cancer cell suspension.