Methods of treating androgen deficiency in men using selective antiestrogens
View Patent ↗The administration of antiestrogens to men suffering a relative androgen deficiency stimulates the body's production of testosterone leading to a correction of the deficiency. For example, male menopause, loss of cognitive function, insulin resistance, type 2 diabetes, obesity, excessive weight, Alzheimer's disease, and combinations thereof, can all be characterized by significant decreases in serum levels of bioavailable androgens. Administration of antiestrogens to men restores optimum serum levels of bioavailable androgens, and, thus, serves as a treatment for these disorders and relative androgen deficiency in general.
1. A method for treating a decline in cognitive function related to male menopause in men comprising administering a selective antiestrogen.
2. A method for treating Alzheimer's disease related to male menopause in men comprising administering a selective antiestrogen.
3. A method for treating insulin resistance related to male menopause in men comprising administering a selective antiestrogen.
4. A method for treating weight gain related to male menopause comprising administering a selective antiestrogen.
5. A method for treating type 2 diabetes related to male menopause comprising administering a selective antiestrogen.
6. The method according to claim 1 , 2 , 3 , 4 , or 5 , wherein the selective antiestrogen is tamoxifen.
7. The method according to claim 1 , 2 , 3 , 4 , or 5 , wherein the selective antiestrogen is tamoxifen citrate.
8. The method according to claim 1 , 2 , 3 , 4 , or 5 , wherein the selective antiestrogen is clomiphine.
9. The method according to claim 1 , 2 , 3 , 4 , or 5 , wherein the selective antiestrogen is clomiphine citrate.
10. The method according to claim 9 , wherein the clomiphine citrate comprises the cis isomer.
11. The method according to claim 9 , wherein the clomiphine citrate comprises the trans isomer.