Methods of healing wounds and fibrotic disorders using IL-10
The present invention provides IL-10 or a fragment or a partially modified form thereof for use in promoting the healing of wounds and fibrotic disorders with reduced scarring and methods for same.
1. A method of promoting the healing of a wound, or fibrotic disorder, with reduced scarring, the method comprising administering to a patient in need thereof an amount of an agent selected from the group consisting of:
i) human IL-10, and
ii) a partially modified form of human IL-10, that differs from human IL-10 by the addition, deletion or substitution of at least one amino acid and that has at least 95% homology with human IL-10 and that retains the anti-inflammatory healing functionality of human IL-10,
sufficient to effect said promotion with reduced scarring.
2. The method according to claim 1 , wherein the agent is administered in conjunction with a pharmaceutically acceptable carrier, diluent or excipient.
3. The method according to claim 1 , wherein the agent is administered in conjunction with a composition for promoting the healing of wounds with reduced scarring.
4. The method according to claim 1 , wherein the agent is administered in conjunction with a composition for promoting the healing of chronic wounds.
5. The method according to claim 1 , wherein the agent is administered to a wound site or site of a fibrotic disorder.
6. The method according to claim 1 , wherein the agent is administered at a concentration of between about 1 μM and about 10 μM.
7. The method according to claim 6 , wherein the agent is administered at a concentration of between about 2.5 μM and about 5 μM.