Method of delaying ejaculation
The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation.
1. A method of delaying ejaculation during sexual intercourse comprising administering orally to a human male who suffers from premature ejaculation prior to the sexual intercourse an effective amount of a compound selected from the group consisting of tramadol, a pharmaceutically-acceptable form of tramadol, tramadol-oxide, a pharmaceutically-acceptable form of tramadol N-oxide, O-desmethyl tramadol, a pharmaceutically-acceptable form of O-desmethyl tramadol and mixtures of the foregoing.
2. The method of claim 1 wherein the compound is tramadol or a pharmaceutically-acceptable salt thereof.
3. The method of claim 2 wherein the tramadol is (±) cis-tramadol or a pharmaceutically-acceptable salt thereof.
4. The method of claim 3 wherein a dose of from about 10 to about 50 milligrams of the tramadol or the pharmaceutically-acceptable salt thereof is administered to the male.
5. The method of claim 4 wherein a dose of from about 15 to about 35 milligrams of the tramadol or the pharmaceutically-acceptable salt thereof is administered to the male.
6. The method of claim 4 wherein a dose of about 25 milligrams of the tramadol or the pharmaceutically-acceptable salt thereof is administered to the male.
7. The method of claim 3 wherein a (+)-enantiomer of the cis-tramadol or the pharmaceutically-acceptable salt thereof is administered to the male.
8. The method of claim 3 wherein a (−)-enantiomer of the cis-tramadol or the pharmaceutically-acceptable salt thereof is administered to the male.
9. The method of claim 3 wherein the tramadol material is (±) cis-tramadol hydrochloride.
10. The method of claim 9 wherein a dose of from about 10 to about 50 milligrams of the tramadol hydrochloride is administered to the male.
11. The method of claim 10 wherein a dose of from about 15 to about 35 milligrams of the tramadol hydrochloride is administered to the male.
12. The method of claim 10 wherein a dose of about 25 milligrams of the tramadol hydrochloride is administered to the male.
13. The method of any one of claims 1 – 12 or 14 – 17 wherein the compound is administered from about 30 minutes to about 60 minutes prior to sexual intercourse.
14. The method of claim 4 wherein a dose of from about 10 to about 35 milligrams of the tramadol or the pharmaceutically-acceptable salt thereof is administered to the male.
15. The method of claim 4 wherein a dose of from about 25 to about 35 milligrams of the tramadol or the pharmaceutically-acceptable salt thereof is administered to the male.
16. The method of claim 10 wherein a dose of from about 10 to about 35 milligrams of the tramadol or the pharmaceutically-acceptable salt thereof is administered to the male.
17. The method of claim 10 wherein a dose of from about 25 to about 35 milligrams of the tramadol or the pharmaceutically-acceptable salt thereof is administered to the male.