Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an inflammation disease or a reperfusion disease comprising administering an effective amount of an inosine compound to a patient in need thereof are disclosed.
1. A method for treating an inflammatory bowel disease, comprising administering to a patient in need thereof an effective amount of a compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein;
R 1 is C 2 -C 6 acyl, SO 3 H or P 2 O 6 H 3 ; and
R 2 , R 3 and R 4 are independently H, C 2 -C 6 acyl, SO 3 H, PO 3 H 2 , P 2 O 6 H 3 or P 3 O 9 H 4 .
2. The method of claim 1 , wherein R 1 is C 2 -C 6 acyl, or SO 3 H, or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , wherein R 1 is SO 3 H, or a pharmaceutically acceptable salt thereof.
4. The method of claim 1 , wherein R 1 is P 2 O 6 H 3 , or a pharmaceutically acceptable salt thereof.
5. The method of claim 1 , wherein R 1 is C 2 -C 6 acyl.
6. The method of claim 5 , wherein the C 2 -C 6 acyl is acetyl.
7. The method of claim 1 , wherein the inflammatory bowel disease is ulcerative colitis or Crohn's disease.
8. A method for treating an inflammatory bowel disease, comprising administering to a patient in need thereof an effective amount of a compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is C 2 -C 6 acyl, SO 3 H, PO 3 H 2 , P 2 O 6 H 3 or P 3 O 9 H 4 ; and
R 2 , R 3 and R 4 are independently H, C 2 -C 6 acyl, SO 3 H, PO 3 H 2 , P 2 O 6 H 3 or P 3 O 9 H 4 .
9. The method of claim 8 , wherein:
R 1 in SO 3 H, or a pharmaceutically acceptable salt thereof; and
R 2 , R 3 and R 4 are H.
10. The method of claim 8 , wherein:
R 1 is PO 3 H 2 , or a pharmaceutically acceptable salt thereof; and
R 2 , R 3 and R 4 are H.
11. The method of claim 8 wherein:
R 1 is P 2 O 6 H 3 , or a pharmaceutically acceptable salt thereof; and
R 2 , R 3 and R 4 are H.
12. The method of claim 8 wherein:
R 1 is a C 2 -C 6 acyl, and
R 2 , R 3 and R 4 are H.
13. A method for treating an inflammatory bowel disease, comprising orally or enterally administering to a patient in need thereof an effective amount of a compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R 1 , R 2 , R 3 and R 4 are each independently H, C 2 -C 6 acyl, SO 3 H, PO 3 H 2 , P 2 O 6 H 3 or P 3 O 9 H 4 .
14. The method of claim 13 , where R 1 , R 2 , R 3 and R 4 are H.
15. The method of claim 13 , where R 1 is SO 3 H, or a pharmaceutically acceptable salt thereof, and R 2 , R 3 and R 4 are H.
16. The method of claim 13 where R 1 is PO 3 H 2 , or a pharmaceutically acceptable salt thereof, and R 2 , R 3 and R 4 are H.
17. The method of claim 13 where R 1 is P 2 O 6 H 3 , or a pharmaceutically acceptable salt thereof, and R 2 , R 3 and R 4 are H.
18. The method of claim 13 where R 1 is P 3 O 9 H 4 , or a pharmaceutically acceptable salt thereof, and R 2 , R 3 and R 4 are H.
19. The method of claim 13 where R 1 is C 2 -C 6 acyl, and R 2 , R 3 and R 4 are H.
20. The method of claim 1 , wherein the R 2 , R 3 and R 4 are —H; and R 1 is —SO 3 − Na + .
21. The method of claim 8 , wherein the R 2 , R 3 and R 4 are —H; and R 1 is —SO 3 − Na + .
22. The method of claim 13 , wherein the R 2 , R 3 and R 4 are —H; and R 1 is —SO 3 − Na + .
23. The method of claim 8 wherein:
R 1 is P 3 O 9 H 4 , or a pharmaceutically acceptable salt thereof; and
R 2 , R 3 and R 4 are H.
24. The method of claim 13 , wherein the administering is orally administering.
25. The method of claim 13 , wherein the administering is enterally administering.
26. The method of claim 8 , wherein the inflammatory bowel disease is Crohn's disease.
27. The method of claim 8 , wherein the inflammatory bowel disease is ulcerative colitis.
28. The method of claim 13 , wherein the inflammatory bowel disease is Crohn's disease.
29. The method of claim 13 , wherein the inflammatory bowel disease is ulcerative colitis.