Antiviral agents and methods of treating viral infections
View Patent ↗The present invention relates to methods of treating viral or fungal infections using 3-aminopyridine-2-carboxyaldehyde thiosemicarbazone (3-AP) and 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) and its prodrug forms and to pharmaceutical compositions comprising these compounds.
1. A method of treating an HIV infection in a patient in need thereof comprising administering to said patient in combination, an effective amount of at least one compound according to the structure:
Where R 1 and R 2 are both H, with an effective amount of at least one anti-HIV agent selected from the group consisting of ddI and D4T, said administration producing a synergistic effect in treating said patient.
2. The method according to claim 1 wherein said anti-HIV agent is ddI.
3. The method according to claim 1 wherein said anti-HIV agent is D4T.
4. A method of treating an HSV infection in a patient in need thereof comprising administering in combination, an effective amount of at least one compound according to the structure:
Where R 1 and R 2 are both H, with an effective amount of acyclovir.