IP Library Granted Patent US 7,070,924
Granted Patent B1
US 7,070,924 · App. 10/129,644 · Granted Jul 4, 2006

Method of detecting cell death and detection reagent

Assignee: EISAI Co., Ltd.
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Quick Facts
Patent No.
US 7,070,924
App. No.
10/129,644
Granted
Jul 4, 2006
Kind
B1
Abstract

A method for detecting cell death, which comprises determining cytochrome C in body fluid and detecting cell death based on a quantified value, as well as a method for determining cytochrome C in body fluid by a sandwich method and a reagent for measuring cytochrome C for determination cytochrome C in body fluid by a sandwich method, which comprises an antibody directed to cytochrome C as an ingredient.

Claims (17)

1. A method for detecting apoptosis, which comprises:

measuring a level of cytochrome C in a body fluid and

detecting apoptosis based on the level of cytochrome C measured in the measuring step.

2. The method according to claim 1 , wherein the level of cytochrome C is measured by an immunochemical method.

3. A method for diagnosing graft versus host disease, which comprises:

measuring a level of cytochrome C in a body fluid, and

diagnosing graft versus host disease based on the level of cytochrome C measured in the measuring step.

4. A method for diagnosing hemophagocytic syndrome, which comprises:

measuring a level of cytochrome C in a body fluid, and

diagnosing hemophagocytic syndrome based on the level of cytochrome C measured in the measuring step.

5. A method for diagnosing acute lymphatic leukemia, which comprises:

measuring a level of cytochrome C in a body fluid, and

diagnosing acute lymphatic leukemia based on the level of cytochrome C measured in the measuring step.

6. A method for diagnosing viral encephalitis or encephalopathy, which comprises:

measuring a level of cytochrome C in a body fluid, and

diagnosing viral encephalitis or encephalopathy based on the level of cytochrome C measured in the measuring step.

7. The method according to claim 6 , wherein the viral encephalitis or encephalopathy is influenzal encephalitis or encephalopathy.

Assignments (4)
MERGER AND CHANGE OF NAME Recorded Oct 11, 2017
From: EIDIA CO., LTD.; SEKISUI MEDICAL CO., LTD.
To: SEKISUI MEDICAL CO., LTD.
Reel/Frame 044219/0293 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2016
From: EISAI R & D MANAGEMENT CO., LTD.
To: EIDIA CO., LTD.
Reel/Frame 038533/0863 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2007
From: EISAI CO., LTD.
To: EISAI R&D MANAGEMENT CO., LTD.
Reel/Frame 019235/0487 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2002
From: ENDO, FUMIO; ADACHI, NAOTO; NUNOI, HIROYUKI; WATANABE, KEISUKE
To: EISAI CO., LTD.
Reel/Frame 013092/0184 →
Priority Claims (2)
JP 11-316475 · Nov 8, 1999 · national
JP 2000-274257 · Sep 11, 2000 · national