Estriol therapy for multiple sclerosis and other autoimmune diseases
View Patent ↗The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, more particularly, Th1-mediated (cell-mediated) autoimmune diseases including: multiple sclerosis (MS), rheumatoid arthritis (RA), autoimmune thyroiditis and uveitis. Most preferably the invention is used to treat a patient with a therapeutically effective amount of estriol of 8 milligrams once daily via oral administration to treat the symptoms or prevent the onset of multiple sclerosis.
1. A method of treating a patient exhibiting clinical symptoms of multiple sclerosis comprising administering 8 milligrams of estriol orally each 24 hours to ameliorate the disease.
2. The method of claim 1 , further comprising administering at least one secondary agent at a therapeutically effective dosage in an effective dosage form at a selected interval.
3. The method of claim 1 wherein the multiple sclerosis is a relapsing remitting form or secondary progressive form of multiple sclerosis.
4. The method of claim 1 wherein the patient is a male or female.
5. A method of treating a patient exhibiting clinical symptoms of multiple sclerosis to ameliorate the disease comprising administering estriol at a dose of about 4 to about 16 milligrams of estriol each 24 hours; and interferon β- 1 a at a dose of about 0mg to about 30 mcg each week.
6. A method of treating a patient exhibiting clinical symptoms of multiple sclerosis to ameliorate the disease comprising administering estriol at a dose of about 4 to about 16 milligrams of estriol each 24 hours; and interferon β- 1 b at a dose of about 0 mg to about 0.25 mg every other day.