IP Library › Granted Patent US 7,166,467
Granted Patent B2
US 7,166,467 · App. 10/141,647 · Granted Jan 23, 2007

Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis

Assignee: Senesco Technologies, Inc.
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Quick Facts
Patent No.
US 7,166,467
App. No.
10/141,647
Granted
Jan 23, 2007
Kind
B2
Abstract

The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Claims (2)

1. A method for increasing apoptosis in vitro in a mammalian cell comprising administering to the cell a polynucleotide encoding apoptosis-specific eIF-5A comprising SEQ ID NO: 1 wherein said apoptosis-specific eIF-5A is expressed within the cell thereby increasing apoptosis in the cell as compared to the level of apoptosis in cells not having been administered said polynucleotide.

2. The method of claim 1 , wherein the polynucleotide encoding apoptosis-specific eIF-5A is in an expression vector.

Assignments (3)
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY Recorded Mar 25, 2010
From: YA GLOBAL INVESTMENTS, L.P.
To: SENESCO TECHNOLOGIES, INC.; SENESCO, INC.
Reel/Frame 024128/0676 →
SECURITY AGREEMENT Recorded Feb 5, 2008
From: SENESCO TECHNOLOGIES, INC.; SENESCO, INC.
To: YA GLOBAL INVESTMENTS, L.P.
Reel/Frame 020468/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 12, 2002
From: TAYLOR, CATHERINE; WANG, TZANN-WEI; PETROV, LARRY; CARLSON, JOHN C.; NARAYANSINGH, RICHARD; KAUP, MARIANNE; CLICHE, DOMINIC; THOMPSON, JOHN C.
To: SENESCO TECHNOLOGIES, INC.
Reel/Frame 013487/0945 →
Continuity (2)
Continuation In Part 0990979600 · Jul 23, 2001
Related Publication 20030064952A1 · Apr 3, 2003