Methods for the treatment or inhibition of ileus
View Patent ↗Methods for the treatment of ileus are disclosed wherein the peripheral mu opioid antagonist methylnaltrexone is administered.
1. A method of treating or inhibiting ileus comprising administering to a patient an effective amount of a peripheral mu opioid antagonist compound, wherein said peripheral mu opioid antagonist compound is the quaternary morphinan compound N-methylnaltrexone.
2. A method according to claim 1 wherein the ileus is selected from the group consisting of postsurgical ileus and postpartum ileus.
3. A method according to claim 2 wherein the ileus is post-surgical ileus.
4. A method according to claim 3 wherein said postsurgical ileus is postsurgical paralytic ileus.
5. A method according to claim 1 wherein the ileus is ileus of the colon.
6. A method according to claim 1 wherein the ileus occurs in the absence of exogenous opioid agonists.
7. A method according to claim 1 further comprising administering an opiate or an opioid to said patient.
8. A method according to claim 7 wherein said opiate or opioid comprises an opioid analgesic.
9. A method according to claim 8 wherein said opioid analgesic comprises a mu opioid agonist.
10. A method according to claim 1 further comprising administering to said patient a compound which slows gut motility.