Antitumor agents
The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.
1. A compound of formula I:
wherein Y is F, Cl, Br, methyl or methoxy; or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein Y is F.
3. The compound of claim 1 , wherein Y is Cl.
4. The compound of claim 1 , wherein Y is Br.
5. The compound of claim 1 , wherein Y is —OMe.
6. The compound of claim 1 , wherein Y is methyl.
7. The compound of claim 1 , wherein the 2-carbon atom of acetic acid is substituted with a methyl group in the (R) configuration.
8. The compound of claim 1 , wherein the 2-carbon atom of acetic acid is substituted with a methyl group in the (S) configuration.
9. A compound of claim 1 which is 2-[4-(7-chloroquinolin-2-yloxy)phenoxy]propanoic acid.
10. A compound of claim 1 which is (R) 2-[4-(7-chloroquinolin-2-yloxy)phenoxy]propanoic acid.
11. A composition comprising a compound of, formula (I):
wherein Y is F, Cl, Br, methyl or methoxy; or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable diluent or carrier.
12. A therapeutic method to treat cancer in a mammal, comprising administering to a mammal in need of such therapy an effective amount of a compound of, formula (I):
wherein Y is F, Cl, Br, methyl or methoxy; or a pharmaceutically acceptable salt thereof.
13. The composition of claim 11 , wherein Y is F.
14. The composition of claim 11 , wherein Y is Cl.
15. The composition of claim 11 , wherein Y is Br.
16. The composition of claim 11 , wherein Y is —OMe.
17. The composition of claim 11 , wherein Y is methyl.
18. The composition of claim 11 , wherein the 2-carbon atom of acetic acid is substituted with a methyl group in the (R) configuration.
19. The composition of claim 11 , wherein the 2-carbon atom of acetic acid is substituted with a methyl group in the (S) configuration.
20. The composition of claim 11 , wherein the compound of formula (I) is 2-[4-(7-chloroquinolin-2-yloxy)phenoxy]propanoic acid.
21. The composition of claim 11 , wherein the compound of formula (I) is (R) 2-[4-(7-chloroquinolin-2-yloxy)phenoxy]propanoic acid.
22. The method of claim 12 , wherein Y is F.
23. The method of claim 12 , wherein Y is Cl.
24. The method of claim 12 , wherein Y is Br.
25. The method of claim 12 , wherein Y is —OMe.
26. The method of claim 12 , wherein Y is methyl.
27. The method of claim 12 , wherein the 2-carbon atom of acetic acid is substituted with a methyl group in the (R) configuration.
28. The method of claim 12 , wherein the 2-carbon atom of acetic acid is substituted with a methyl group in the (S) configuration.
29. The method of claim 12 , wherein the compound of formula (I) is 2-[4-(7-chloroquinolin-2-yloxy)phenoxy]propanoic acid.
30. The method of claim 12 , wherein the compound of formula (I) is (R) 2-[4-(7-chloroquinolin-2-yloxy)phenoxy]propanoic acid.
31. The method of claim 12 , wherein the cancer is colon cancer, breast cancer, melanoma, pancreatic cancer or leukemia.