Detection of carbon halogen bonds
View Patent ↗Detecting and determination of halooorganic compounds is described, which is applicable in the pharmaceutical industry, in fluorinated drug research and manufacturing; in the medical and clinical studies of the effects of fluoroorganic compounds; in the environmental and agricultural studies and screening, in the analysis of water, soils and air contaminated with fluoroorganic compounds.
1. A method, comprising:
providing a sample having a compound, biological molecule, bioprobe, material or product containing at least one carbon-halogen bond;
applying a non-continuous light source to cause the sample to emit secondary emissions; and
detecting at least one isochronic spectrum indicative of the at least one carbon halogen bond.
2. The method of claim 1 , wherein the applying the non-continuous light source further comprises exposing the sample to a pulsed metal-vapor laser.
3. The method of claim 1 , wherein the detecting at least one isochronic spectrum further comprises delaying the detection of secondary emissions of the at least one carbon halogen bond using a time delay device.
4. The method of claim 1 , wherein the detecting at least one isochronic spectrum further comprises detecting the secondary emissions prior to fluorescence being emitted from the sample.
5. The method of claim 1 , wherein the detecting at least one isochronic spectrum further comprises detecting the secondary emissions after detecting a Raman emission from the sample.
6. The method of claim 1 , wherein the non-continuous light source comprises one of a gold-vapor laser, copper-vapor laser, solid-state laser, copper and gold vapor laser, a lead vapor laser, and a barium vapor laser.
7. The method of claim 1 , wherein the at least one carbon-halogen bond comprises at least one carbon-fluorine bond and the applying the non-continuous light source comprises producing secondary emissions permitting detecting a fully symmetric vibrational normal mode of the at least one carbon-fluorine bond.
8. The method of claim 1 , wherein the non-continuous light source further emits a wavelength that induces Raman scattered light emissions from the at least one carbon-halogen bond.
9. The method of claim 8 , wherein three wavelengths inducing Raman scattered light emissions are approximately 510.6 nm, approximately 578.2 nm, and approximately 627.8 nm.
10. The method of claim 1 , wherein the applying the non-continuous light source further comprises time-gating the non-continuous light source.
11. The method of claim 1 , wherein the secondary emissions comprise Raman, resonance Raman, surface enhanced Raman and surface enhanced resonance Raman signatures.