Vehicle for topical delivery of anti-inflammatory compounds
A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds.
1. A composition for topical application comprising a non-steroidal anti-inflammatory drug selected from the group consisting of diclofenac and piroxicam and a solvent vehicle for solubilizing said non-steroidal anti-inflammatory drug, said solvent vehicle consisting essentially of: a liquid eutectic mixture of camphor and menthol and optionally a liquid hydrophobic component, wherein the camphor and menthol are present in the eutectic mixture in a ratio from 4:1 to 1:4.
2. The composition of claim 1 , wherein the ratio of said camphor and menthol are present in said eutectic mixture in a ratio from 2:1 and 1:2.
3. The composition of claim 1 wherein the drug is diclofenac.
4. The composition of claim 1 wherein the drug is piroxicam.
5. The composition of claim 1 wherein said camphor is selected from the group consisting of D-isomer, L-isomer, racemic camphor or a mixture of camphor isomers.
6. The composition of claim 1 wherein said menthol is selected from the group consisting o D-isomer, L-isomer, racemic menthol or a mixture of menthol isomers.
7. The composition of claim 1 wherein the hydrophobic component is tocopherol.
8. The composition of claim 7 , wherein the tocopherol is alpha-tocopherol or tocopherol acetate.
9. A composition for topical application comprising a non-steroidal anti-inflammatory drug selected from the group consisting of: diclofenac, piroxicam, and indomethacin, and a solvent vehicle for solubilizing said non-steroidal anti-inflammatory drug, said solvent vehicle consisting essentially of: medium chain triglycerides and a liquid eutectic mixture of camphor and menthol and optionally a liquid hydrophobic component, wherein the camphor and menthol are present in the eutectic mixture in a ratio from 4:1 to 1:4.
10. The composition of claim 9 , wherein the ratio of said camphor and menthol are present in said eutectic mixture in a ratio from 2:1 to 1:2.
11. The composition of claim 9 wherein the drug is diclofenac.
12. The composition of claim 9 wherein the drug is piroxicam.
13. The composition of claim 9 wherein the drug is indomethacin.
14. The composition of claim 9 wherein said camphor is selected from the group consisting of D-isomer, L-isomer, racemic camphor or a mixture of camphor isomers.
15. The composition of claim 9 wherein said menthol is selected from the group consisting of D-isomer, L-isomer, racemic menthol or a mixture of menthol isomers.
16. The composition of claim 9 wherein said hydrophobic component is tocopherol.
17. The composition of claim 16 , wherein the tocopherol is alpha-tocopherol or tocopherol acetate.
18. A composition for topical application comprising the non-steroidal anti-inflammatory drug piroxicam and a solvent vehicle for solubilizing piroxicam, said vehicle consisting essentially of: medium chain triglycerides and a liquid eutectic mixture of camphor and thymol and optionally a liquid hydrophobic component, wherein the MCT:camphor:thymol are present in a ratio of 2:5:5.
19. The composition of claim 18 wherein said camphor is selected from the group consisting of D-isomer, L-isomer, racemic camphor or a mixture of camphor isomers.
20. The composition of claim 18 wherein the hydrophobic component is tocopherol.
21. The composition of claim 20 , wherein the tocopherol is alpha-tocopherol or tocopherol acetate.