Method and apparatus for treating vulnerable plaque
An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.
1. A method comprising:
implanting a stent graft into a body lumen near a vulnerable plaque region, wherein the stent graft has an expandable tube coupled to an inner surface of a stent and a layer of endothelial cells seeded on an inner surface of the expandable tube, and
shielding the vulnerable plaque with the stent graft, wherein the stent graft prevents the vulnerable plaque from rupturing into the body lumen.
2. The method of claim 1 , wherein implanting the stent graft comprises expanding the stent graft near the vulnerable plaque.
3. The method of claim 1 , further comprising coating the stent graft with a vulnerable plaque biologically active agent.
4. The method of claim 3 , further comprising treating the vulnerable plaque with the vulnerable plaque biologically active agent.
5. The method of claim 1 , further comprising strengthening a fibrous cap of the vulnerable plaque.
6. The method of claim 1 , wherein the stent graft comprises a material that is selected from the group consisting of a bioerodable material, a biodegradable polymeric material, a bioerodable material coated with a biologically active agent, and a biodegradable polymeric material coated with a biologically active agent.
7. The method of claim 1 further comprising forming a monolayer of the endothelial cells near the vulnerable plaque region.
8. The method of claim 7 wherein forming comprises the endothelial cells migrating from the inner surface of the expandable tube to a lumen wall near the vulnerable plaque.