1,4-diazabicyclo[3.2.2]nonabenzoxazole, -benzothiazole and benzimidazole derivatives, preparation and therapeutic use thereof
View Patent ↗Compound corresponding to the general formula (I) in which X represents an oxygen or sulphur atom or an NH group and R 1 , R 2 , R 3 and R 4 each represent a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoroalkoxy, cyano, hydroxyl, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy or phenyl group. Application in therapeutics.
1. A compound of formula (I)
in which
X represents an oxygen or sulphur atom or an NH group and R 1 , R 2 , R 3 and R 4 each represent, independently of one another, a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoroalkoxy, cyano, hydroxyl, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy or phenyl group, or a pharmaceutically acceptable salt thereof.
2. A process for the preparation of a compound according to claim 1 wherein 1,4-diazabicyclo[3.2.2]nonane is reacted with a compound formula (III)
in which R 1 , R 2 , R 3 and R 4 are as defined in claim 1 and W represents a halogen atom or a methylthio group.
3. A method for the treatment or prevention of symptoms due to weaning from tobacco, which comprises administering to a patient in need of such treatment an effective amount of a compound according to claim 1 .
4. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 , in combination with an excipient.