1,4-diazabicyclo[3.2.2]nonane-phenylisoxazole derivatives, their preparation and their application in therapeutics
View Patent ↗Compounds corresponding to general formula (I) in which R 1 , R 2 , R 3 , R 4 and R 5 each represent, independently of one another, a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy or phenyl group, it also being possible for two of these substituents in adjacent positions together to represent a methylenedioxy group, and R 6 represents a hydrogen atom or a (C 1 -C 6 )alkyl group. Application in therapeutics.
1. A compound corresponding to general formula (I)
in which R 1 , R 2 , R 3 , R 4 and R 5 each represent, independently of one another, a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy or phenyl group, it also being possible for two of these substituents in adjacent positions together to represent a methylenedioxy group, and
R 6 represents a hydrogen atom or a (C 1 -C 6 )alkyl group or a pharmaceutically acceptable salt thereof.
2. A method for preparing a compound of Formula I as claimed in claim 1 wherein 1,4-diazabicyclo[3.2.2]nonane is reacted with a compound of formula (IIIa) or (IIIb)
in which R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in claim 1 , and then the compound of general formula (IV)
thus obtained is cyclized with hydroxylamine to afford a compound of Formula I.
3. A pharmaceutical composition comprising an effective amount of a compound as claimed in claim 1 , in combination with an excipient.