Container for medicament powder
There is provided a container for a medicament powder formed from a material comprising a desiccant. In one embodiment the container is a medicament dispenser comprising a body defining a reservoir for medicament in powder form, and an outlet in communication with said reservoir. In another embodiment the container is a medicament dispenser comprising a body defining a chamber for receipt of a medicament carrier, and an outlet in communication with said chamber. Methods of controlling moisture flow are also described.
1. A medicament carrier adapted for use in a dry powder inhaler, wherein the medicament carrier is a laminate multi-unit blister pack comprising a base sheet, in which are formed multiple pockets in series arrangement, each pocket containing a dose of inhalable dry powder medicament in free contact with the base sheet, and a lid to cover the multiple pockets, wherein the laminate multi-unit blister pack includes a metal foil and a layer of an organic polymeric plastic material comprising a desiccant impregnated therein.
2. The carrier according to claim 1 , wherein the laminate multi-unit blister pack additionally comprises a paper material.
3. The carrier according to claim 1 , wherein the metal foil is an aluminum or tin foil having a thickness of from 5 to 100 μm.
4. The carrier according to claim 1 , wherein the organic polymeric plastic material is selected from the group consisting of polyethylene, polypropylene, polyvinyl chloride and polyethylene terephthalate.
5. The carrier according to claim 1 , wherein the desiccant is selected from the group consisting of silica gel, zeolite, alumina, bauxite, anhydrous calcium sulphate, activated bentonite clay, water-absorbing clay, molecular sieve and any mixtures thereof.
6. The carrier according to claim 1 , wherein the base sheet has the layer of the organic polymeric plastic material comprising the desiccant impregnated therein.
7. The carrier according to claim 6 , wherein the layer of the organic polymeric plastic material comprising the desiccant impregnated therein is the innermost layer of the base sheet.
8. The carrier according to claim 6 , wherein the organic polymeric plastic material is selected from the group consisting of polyethylene, polypropylene, polyvinyl chloride and polyethylene terephthalate.
9. The carrier according to claim 6 , wherein the desiccant is selected from the group consisting of silica gel, zeolite, alumina, bauxite, anhydrous calcium sulphate, activated bentonite clay, water-absorbing clay, molecular sieve and any mixtures thereof.
10. The carrier according to claim 6 , wherein the lid includes the metal foil.
11. The carrier according to claim 1 , wherein the medicament is suitable for the treatment of respiratory disorders.
12. The carrier according to claim 1 , wherein said medicament is salmeterol xinafoate.
13. The carrier according to claim 1 , wherein said medicament is fluticasone propionate.
14. The carrier according to claim 1 , wherein said medicament is a combination of salmeterol xinafoate and fluticasone propionate.
15. A dry powder inhaler which contains a carrier according to claim 1 and which is configured and arranged to open the at least one pocket to enable dispensing of the powder from the inhaler.
16. A medicament carrier adapted for use in a dry powder inhaler, wherein the medicament carrier is a laminate multi-unit blister pack comprising a base sheet, in which are formed multiple pockets in series arrangement, each pocket containing a dose of inhalable dry powder medicament in free contact with the base sheet, and a lid to cover the multiple pockets, wherein the laminate multi-unit blister pack includes a metal foil and wherein the base sheet has a layer of an organic polymeric plastic material comprising a desiccant impregnated therein.
17. The carrier according to claim 16 , wherein the laminate multi-unit blister pack additionally comprises a paper material.
18. The carrier according to claim 16 , wherein the metal foil is an aluminium or tin foil having a thickness of from 5 to 100 μm.
19. The carrier according to claim 16 , wherein the organic polymeric plastic material is selected from the group consisting of polyethylene, polypropylene, polyvinyl chloride and polyethylene terephthalate.
20. The carrier according to claim 16 , wherein the desiccant is selected from the group consisting of silica gel, zeolite, alumina, bauxite, anhydrous calcium sulphate, activated bentonite clay, water-absorbing clay, molecular sieve and any mixtures thereof.
21. The carrier according to claim 16 , wherein the layer of the organic polymeric plastic material comprising the desiccant impregnated therein is the innermost layer of the base sheet.
22. The carrier according to claim 16 , wherein the lid includes the metal foil.
23. The carrier according to claim 16 , wherein the medicament is suitable for the treatment of respiratory disorders.
24. The carrier according to claim 16 , wherein said medicament is salmeterol xinafoate.
25. The carrier according to claim 16 , wherein said medicament is fluticasone propionate.
26. The carrier according to claim 16 , wherein said medicament is a combination of salmeterol xinafoate and fluticasone propionate.
27. A multiple unit dose dry powder inhaler which contains therein a carrier according to claim 16 and which is configured and arranged to open the pockets of the medicament carrier to enable a unit dose of the powder to be repeatedly dispensed from the inhaler.
28. A medicament carrier adapted for use in a dry powder inhaler, wherein the medicament carrier is a laminate multi-unit blister pack comprising a base sheet, in which are formed multiple pockets in series arrangement, each pocket containing a dose of inhalable dry powder medicament in free contact with the base sheet, and a lid to cover the at least one pocket, wherein the base sheet and the lid of the laminate multi-unit blister pack include a metal foil, and wherein the base sheet has a layer of an organic polymeric plastic material comprising a desiccant impregnated therein.
29. The carrier according to claim 28 , wherein the laminate blister pack additionally comprises a paper material.
30. The carrier according to claim 28 , wherein the metal foil is an aluminium or tin foil having a thickness of from 5 to 100 μm.
31. The carrier according to claim 28 , wherein the organic polymeric plastic material is selected from the group consisting of polyethylene, polypropylene, polyvinyl chloride and polyethylene terephthalate.
32. The carrier according to claim 28 , wherein the desiccant is selected from the group consisting of silica gel, zeolite, alumina, bauxite, anhydrous calcium sulphate, activated bentonite clay, water-absorbing clay, molecular sieve and any mixtures thereof.
33. The carrier according to claim 28 , wherein the layer of the organic polymeric plastic material comprising the desiccant impregnated therein is the innermost layer of the base sheet.
34. The carrier according to claim 28 , wherein the medicament is suitable for the treatment of respiratory disorders.
35. The carrier according to claim 28 , wherein said medicament is salmeterol xinafoate.
36. The carrier according to claim 28 , wherein said medicament is fluticasone propionate.
37. The carrier according to claim 28 , wherein said medicament is a combination of salmeterol xinafoate and fluticasone propionate.
38. A multiple unit dose dry powder inhaler which contains a carrier according to claim 28 and which is configured and arranged to open the pockets of the medicament carrier to enable a unit dose of the powder to be repeatedly dispensed from the inhaler.