Tissue regenerative composition, method of making, and method of use thereof

1. A matrix, comprising:

a devitalized mammalian epithelial basement membrane of the urinary bladder and tunica propria immediately subjacent to said basement membrane wherein said matrix induces restoration, remodeling, or repair of a tissue of the gastrointestinal tract when placed in contact with a diseased, damaged, or defective tissue of the gastrointestinal tract.

2. The matrix of claim 1 , wherein said matrix is shaped to conform to said diseased, damaged, or defective tissue of the gastrointestinal tract.

3. The matrix of claim 1 wherein said matrix comprises an injectable form of said matrix.

4. The matrix of claim 1 wherein said matrix further comprises a pharmaceutical agent.

5. The matrix of claim 1 wherein said tissue of the gastrointestinal tract is the esophagus.

6. The matrix of claim 1 wherein said tissue of the gastrointestinal tract is the stomach.

7. The matrix of claim 1 wherein said tissue of the gastrointestinal tract is the intestine.

8. The matrix of claim 1 wherein said tissue of the gastrointestinal tract is the liver.

9. The matrix of claim 1 wherein said tissue of the gastrointestinal tract is the pancreas.

10. The matrix of claim 1 wherein said tissue of the gastrointestinal tract is the gall bladder.

11. The matrix of claim 1 wherein said tissue of the gastrointestinal tract is the biliary tract.

12. The matrix of claim 1 wherein said matrix is shaped to conform to a missing tissue of the gastrointestinal tract.

13. The matrix of claim 1 wherein said matrix comprises a soluble form of said matrix.

14. The matrix of claim 1 wherein said matrix comprises a particulate form of said matrix.

15. The matrix of claim 1 wherein said matrix comprises a gel form of said matrix.

16. The matrix of claim 1 wherein said matrix comprises a lyophilized form of said matrix.

17. The matrix of claim 1 wherein said matrix comprises a dehydrated form of said matrix.

18. The matrix of claim 1 wherein said matrix comprises a gene product.

19. A method for inducing restoration, remodeling, or repair of a tissue of the gastrointestinal tract in a mammal, said method, comprising:

contacting a matrix comprising at least a portion of devitalized mammalian epithelial basement membrane of the urinary bladder with diseased, defective, or damaged tissue of the gastrointestinal tract, wherein said matrix induces restoration, remodeling, or repair of said tissue of the gastrointestinal tract.

20. The method of claim 19 wherein said matrix further comprises the tunica propria of the urinary bladder.

21. The method of claim 19 wherein said tissue of the gastrointestinal tract is the esophagus.

22. The method of claim 19 wherein said tissue of the gastrointestinal tract is the stomach.

23. The method of claim 19 wherein said tissue of the gastrointestinal tract is the intestine.

24. The method of claim 19 wherein said tissue of the gastrointestinal tract is the liver.

25. The method of claim 19 wherein said tissue of the gastrointestinal tract is the pancreas.

26. The method of claim 19 , wherein said tissue of the gastrointestinal tract is the gall bladder.

27. The method of claim 19 wherein said tissue of the gastrointestinal tract is the biliary tract.

28. A composition, comprising:

at least a portion of devitalized epithelial basement membrane and tunica propria delaminated from a urinary bladder and shaped to conform to a diseased, damaged, or defective tissue of the gastrointestinal tract.

29. The composition of claim 28 further comprising submucosa.

30. The composition of claim 28 further comprising at least a portion of the tunica muscularis.

31. The composition of claim 28 wherein said tissue is esophagus.

32. The composition of claim 28 wherein said tissue of the gastrointestinal tract is the stomach.

33. The composition of claim 28 wherein said tissue of the gastrointestinal tract is the intestine.

34. The composition of claim 28 wherein said tissue of the gastrointestinal tract is the liver.

35. The composition of claim 28 wherein said tissue of the gastrointestinal tract is the gall bladder.

36. The composition of claim 28 wherein said tissue of the gastrointestinal tract is the pancreas.

37. The composition of claim 28 wherein said tissue of the gastrointestinal tract is the biliary tract.

38. A matrix for restoring, remodeling, replacing or repairing tissue of the gastrointestinal tract, comprising:

a devitalized mammalian epithelial basement membrane of the urinary bladder and tunica propria immediately subjacent to said basement membrane.

39. The matrix of claim 38 wherein the matrix further comprises at least a portion of tunica muscularis.

40. The matrix of claim 38 wherein the matrix further comprises at least a portion of submucosa.

41. The matrix of claim 38 wherein said matrix comprises a synthetic or non-synthetic polymer.

42. The matrix of claim 38 wherein said matrix further comprises a cell.

43. A method for restoring, remodeling, replacing or repairing a tissue of the gastrointestinal tract in a mammal, said method comprising:

applying a matrix comprising at least a portion of devitalized epithelial basement membrane of a mammalian urinary bladder in the mammal having a diseased, defective, or damaged tissue of the gastrointestinal tract.

44. The method of claim 43 wherein said matrix further comprises at least a portion of the tunica propria.

45. The method of claim 43 wherein said matrix further comprises at least a portion of the tunica muscularis.

46. The method of claim 43 wherein said matrix further comprises at least a portion of the submucosa.

47. A composition for restoring, remodeling, replacing, or repairing tissue of the gastrointestinal tract, comprising:

at least a portion of devitalized epithelial basement membrane and tunic a propria delaminated from epithelial tissue of a mammalian urinary bladder.

48. The composition of claim 47 further comprising at least a portion of submucosa.

49. The composition of claim 47 further comprising at least a portion of the tunica muscularis.