Compounds which mimic the chemical and biological properties of discodermolide
View Patent ↗Compounds which mimic the chemical and/or biological activity of discodermolide are provided.
1. A compound having the following structure where the substituents are as set forth:
R 40a
R 25b ; R 25c
H; H
H; H
H; H
H; H
H; H
CH 3
H; H
H; H
H; H
H; H
H; H
H; H
H; H
H; H
CH 3
CH(CH 3 ) 2
CH 2 CH 2 CH 3
—CH(CH 3 )—CH 2 CH 3
3-fluorene
R 6
J
CH 3
H
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
or a pharmaceutically acceptable salt form thereof.
2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, diluent, or excipient and a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.
3. A method for treating cancer comprising stabilizing microtubules, by administering to a patient in need thereof a therapeutically effective amount of a compound according to claim 1 .