IP Library › Granted Patent US 7,186,528
Granted Patent B2
US 7,186,528 · App. 10/311,491 · Granted Mar 6, 2007

Method for preparing a physiologically active IL-18 polypeptide

Assignee: SmithKline Beecham Corporation
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Quick Facts
Patent No.
US 7,186,528
App. No.
10/311,491
Granted
Mar 6, 2007
Kind
B2
Abstract

A method for producing a physiologically active polypeptide, comprising contacting a precursor polypeptide with an activating enzyme, or co-expressing the polypeptide with an activating protease.

Claims (3)

1. A method for producing an active human IL-18 polypeptide from a human precursor IL-18 polypeptide, said method comprising the steps of:

(i) co-expressing bicistronically a caspase 5 polypeptide consisting of the amino acid sequence of SEQ ID NO:6, with a human precursor IL-18 polypeptide consisting of the amino acid sequence of SEQ ID NO:1; and

(ii) purifying the active human IL-18 polypeptide (SEQ ID NO:3).

Assignments (2)
CHANGE OF NAME Recorded Mar 10, 2010
From: SMITHKLINE BEECHAM CORPORATION
To: GLAXOSMITHKLINE LLC
Reel/Frame 024055/0203 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 16, 2002
From: JOHANSON, KYUNG O.; KIRKPATRICK, ROBERT B.; SHATZMAN, ALLAN R.; HO, YEN SEN; MCDEVITT, PATRICK
To: SMITHKLINE BEECHAM CORPORATION
Reel/Frame 013834/0087 →
Continuity (4)
Provisional Application 6021183200 · Jun 15, 2000
Provisional Application 6022412800 · Aug 10, 2000
Provisional Application 6026492300 · Jan 30, 2001
Related Publication 20030143198A1 · Jul 31, 2003