Compositions and methods for thionation during chemical synthesis reactions
Compositions and methods for using these compositions to produce high yields of thionated compounds are provided.
1. A method for producing a thionated compound comprising treating the compound to be thionated with a phosphorus sulfide compound and a siloxane compound so that the compound is thionated.
2. The method of claim 1 wherein the compound to be thionated is an ester or lactone.
3. The method of claim 2 wherein the thionated compound produced is a thionoester or a thionolactone.
4. The method of claim 1 wherein the compound to be thionated is a 3-oxoester compound.
5. The method of claim 4 wherein the thionated compound produced is 3H-1,2-dithiole-3-thione.
6. A method for producing a thionated therapeutic agent comprising treating an ester or lactone with a phosphorus sulfide compound and a siloxane compound to produce the thionated therapeutic agent.
7. The method of claim 6 wherein the ester is a 3-oxoester and the thionated therapeutic agent is a chemopreventive agent 3H-1,2dithiole-3-thione.