IP Library › Granted Patent US 7,053,224
Granted Patent B2
US 7,053,224 · App. 10/369,510 · Granted May 30, 2006

Intermediates and improved processes for the preparation of neplanocin A

Assignee: Chisso Corporation
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Quick Facts
Patent No.
US 7,053,224
App. No.
10/369,510
Granted
May 30, 2006
Kind
B2
Abstract

Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy-tricyclo[5.2.1.0 2,6 dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes for the preparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[5.2.1.0 2,6 ]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reaction of the above intermediate.

Claims (3)

1. A compound of formula (4)

wherein X is halogen and Y is a protecting group.

2. A compound of claim 1 wherein X is Br and Y is t-butyldimethylsilyl.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2011
From: CHISSO CORPORATION
To: JNC CORPORATION
Reel/Frame 026187/0940 →
Priority Claims (1)
JP 10-158687 · May 25, 1998 · national
Continuity (3)
Division 0984935600 · May 7, 2001
Division 0931843500 · May 25, 1999
Related Publication 20030175943A1 · Sep 18, 2003