Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance

1. An 8-azabicyclo[3.2.1]oct-2-ene compound of Formula VI,

any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt thereof; wherein R is hydrogen; and R 1 is benzothienyl.

2. The 8-azabicyclo[3.2.1]oct-2-ene compound of claim 1 , which is

(±)-3-(2-benzothienyl)-8-H-8-azabicyclo[3.2.1 ]oct-2-ene;

or an enantiomer or a mixture of its enantiomers, or a pharmaceutically acceptable salt thereof.

3. A pharmaceutical composition comprising a therapeutically effective amount of the 8-azabicyclol[3.2.1 ]oct-2-ene compound of claim 1 , together with at least one pharmaceutically acceptable carrier or diluent.

4. A method of treatment of an affective disorder, disease, or condition in a subject, which method comprises administering to said subject a therapeutically effective amount of the 8-azabicyclo[3.2.1]oct-2-ene compound of claim 1 .

5. The method of claim 4 , wherein the affective disorder, disease, or condition is depression, anxiety, obsessive compulsive disorder (OCD), or panic disorder.

6. The method of claim 4 , wherein the affective disorder, disease, or condition is pain.

7. The 8-azabicyclo[3.2.1 ]oct-2-ene compound of claim 1 , wherein R is 2-benzothienyl R 1 or 3-benzothienyl.