IP Library Granted Patent US 6,949,637
Granted Patent B2
US 6,949,637 · App. 10/413,255 · Granted Sep 27, 2005

Methods for diagnosis, prediction and treatment of asthma and other inflammatory conditions based on eotaxin coding sequence polymorphism

Assignees: Brigham and Women's Hospital, Inc.; The General Hospital Corporation
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Quick Facts
Patent No.
US 6,949,637
App. No.
10/413,255
Granted
Sep 27, 2005
Kind
B2
Abstract

Methods and compositions for diagnosing and treating asthma are provided. The methods involve the discovery of a correlation between an eotaxin gene polymorphism and the ocurrence of asthma.

Claims (13)

1. A composition comprising an isolated nucleic acid consisting of the wild type normal eotaxin gene sequence as shown in SEQ ID NO: 1, wherein said nucleic acid includes a guanine to adenine substitution 67 base pairs following the ATG initiation codon of the wild type normal eotaxin gene, whereby counting is initiated at the A in that codon.

2. A composition comprising an isolated oligonucleotide consisting of a nucleotide sequence selected from the group consisted of:

AGAAACCACCACCTCTCACG;

(SEQ ID NO: 2)

GAGAATTTGCAGTGAGTCTGT;

(SEQ ID NO: 3)

GGGGCTTACCTGGCCCAAC;

(SEQ ID NO: 4)

GGGGCTTACCTGGCCCAAT;

(SEQ ID NO: 5)

and

TCAAGGAAGGTTCTTAGATCG.

(SEQ ID NO. 6).

Assignments (5)
CONFIRMATORY LICENSE Recorded May 11, 2020
From: BRIGHAM AND WOMEN'S HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 052624/0952 →
CONFIRMATORY LICENSE Recorded Dec 10, 2018
From: BRIGHAM AND WOMEN'S HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 048962/0419 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 29, 2005
From: LILLY, CRAIG M.; LUSTER, ANDREW D.; DRAZEN, JEFFREY M.
To: BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 016592/0677 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 29, 2005
From: BRIGHAM AND WOMEN'S HOSPITAL, INC.
To: LUSTER, ANDREW D.
Reel/Frame 016592/0802 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 29, 2005
From: LUSTER, ANDREW D.
To: GENERAL HOSPITAL CORPORATION, THE
Reel/Frame 016594/0063 →
Continuity (3)
Division 0907625900 · May 12, 1998
Provisional Application 6004672000 · May 16, 1997
Related Publication 20030165980A1 · Sep 4, 2003