Method for achieving tissue changes in bone or bone-derived tissue
View Patent ↗A method of achieving tissue changes in bone or bone-derived organic tissue, in which method bone or bone-derived organic tissue is provided, an interfacing agent is applied to the bone or bone-derived organic tissue, and electromagnetic energy is applied to the interfacing agent. The interfacing agent can include collagen, preferably bone-derived collagen, and a therapeutic agent. In a related embodiment, a method of treating bone tissue is provided wherein a bioactive interfacing agent is placed between the bone segments of the bone tissue to be treated.
1. A method of achieving tissue changes in bone or bone-derived organic tissue comprising the steps of:
providing bone or bone-derived organic tissue in an electrically conductive medium;
applying an interfacing agent to the bone or bone-derived organic tissue; and
applying electromagnetic energy to the interfacing agent while the bone or bone-derived organic tissue is in the electrically conductive medium.
2. The method of claim 1 wherein the applying step comprises applying radio frequency energy.
3. The method of claim 1 wherein the interfacing agent comprises collagen and a therapeutic agent.
4. The method of claim 3 , wherein the collagen is bone-derived collagen.
5. The method of claim 4 , wherein the source of bone-derived collagen is acid treated bone-derived graft material.
6. The method of claim 5 , wherein the acid treated bone-derived graft material is derived from autologous bone of the patient to be treated.
7. The method of claim 3 , wherein the collagen is made by synthetic or recombinant means.
8. The method of claim 3 , wherein the therapeutic agent comprises hydroxyapetite.
9. The method of claim 3 , wherein the therapeutic agent comprises an osteogenic protein.
10. The method of claim 3 , wherein the therapeutic agent comprises a growth factor.
11. The method of claim 1 , wherein the interfacing agent comprises one or more members from the group consisting of osteoconductive, osteoinductive, and osteogenic substances or agents.
12. The method of claim 1 , wherein the interfacing agent comprises a hydrophobic, lipophilic carrier paste-gel-like material.
13. The method of claim 1 , wherein the interfacing agent comprises heat releasing microspheres.