Food supplements containing 4-hydroxyisoleucine and creatine
The present invention provides a dietary or food supplement for healthy humans that includes a combination of 4-hydroxyisoleucine and creatine, or nutraceutically acceptable derivatives of these two compounds. The supplement may include additives such as carbohydrates or amino acids. The invention further includes a regimen for supplementing a healthy athlete's diet by administering on a regular basis to the athlete 4-hydroxyisoleucine and creatine, or nutraceutically acceptable derivatives of these two compounds. The invention also provides a method for enhancing the body's absorption and utilization of a nutrient, comprising administering 4-hydroxyisoleucine or a nutraceutically acceptable derivative thereof in combination with the nutrient.
1. A dietary supplement for use by a healthy human, comprising, per gram of supplement:
about 0.5 milligram to about 100 milligrams of 4-hydroxyisoleucine, a nutraceutically acceptable derivative, or a combination thereof; and
about 0.02 gram to about 0.80 gram of creatine, a nutraceutically acceptable derivative, or a combination thereof.
2. The dietary supplement of claim 1 , comprising about 0.5 milligram to about 100 milligrams of 4-hydroxyisoleucine per gram of supplement.
3. The dietary supplement of claim 1 , comprising about 0.5 milligram to about 100 milligrams of (2S, 3R, 4S) 4-hydroxyisoleucine per gram of supplement.
4. The dietary supplement of claim 1 , comprising about 9 milligrams to about 10 milligrams 4-hydroxyisoleucine per gram of supplement.
5. The dietary supplement of claim 1 , comprising, per gram of supplement, about 0.02 gram to about 0.80 gram creatine phosphate, creatine citrate, magnesium creatine, alkaline creatine, creatine pyruvate, creatine hydrates, tricreatine malate, glycocyamine, or a combination thereof.
6. The dietary supplement of claim 1 , comprising about 0.02 gram to about 0.80 gram creatine monohydrate per gram of supplement.
7. The dietary supplement of claim 1 , comprising about 0.15 gram to about 0.17 gram creatine monohydrate per gram of supplement.
8. The dietary supplement of claim 1 , comprising, per gram of supplement:
about 9 to about 10 milligrams 4-hydroxyisoleucine; and
about 0.15 to about 0.17 gram creatine monohydrate.
9. The dietary supplement of claim 1 , and further comprising about 1 milligram to about 160 milligrams free amino acids per gram of supplement.
10. The dietary supplement of claim 9 , wherein the free amino acids include taurine, glutamine, carnitine, carnosine, citrulline, leucine, glycine, alanine, β-alanine, arginine, or a combination thereof.
11. The dietary supplement of claim 1 , and further comprising about 15 milligrams to about 17 milligrams taurine per gram of supplement.
12. The dietary supplement of claim 1 , and further comprising about 0.5 gram to about 0.8 gram carbohydrates per gram of supplement.
13. The dietary supplement of claim 12 , wherein the carbohydrates include simple sugars.
14. The dietary supplement of claim 13 , wherein the simple sugars include maltose, dextrose, or a combination thereof.
15. The dietary supplement of claim 12 , wherein the carbohydrates include complex carbohydrates.
16. The dietary supplement of claim 15 , wherein the complex carbohydrates include potato starch.
17. The dietary supplement of claim 1 , and further comprising a blood glucose-modifying or blood insulin-modifying agent.
18. The dietary supplement of claim 17 , wherein the blood glucose-modifying or blood insulin-modifying agent is selected from the group consisting of chromium, vanadium, Banaba extract, corosolic acid, α-lipoic acid, D-pinitol, panax ginseng, ginseng extract, ginger, ginger extract, cinnamon, cinnamon extract, and methylhydroxy chalcone polymer.
19. The dietary supplement of claim 1 , further comprising a lactate buffering agent selected from the group consisting of carnosine and β-alanine.
20. The dietary supplement of claim 1 , wherein the supplement is a powder that can be mixed with a fluid to make a beverage.
21. The dietary supplement of claim 20 , wherein the fluid is water.
22. A regimen for supplementing a healthy athlete's diet, comprising administering to the athlete a supplement comprising, per gram of supplement:
about 0.5 milligram to about 100 milligrams of 4-hydroxyisoleucine, a nutraceutically acceptable derivative, or a combination thereof; and
about 0.02 gram to about 0.80 gram of creatine, a nutraceutically acceptable derivative, or a combination thereof.
23. The regimen of claim 22 , wherein about 15 grams to about 400 grams of the supplement are administered to the athlete on a daily basis.
24. A regimen for supplementing a healthy athlete's diet, comprising administering to the athlete, on a daily basis:
about 20 milligrams to about 2 grams of 4-hydroxyisoleucine, a nutraceutically acceptable derivative, or a combination thereof; and
about 2 grams to about 30 grams of creatine, a nutraceutically acceptable derivative, or a combination thereof.
25. The regimen of claim 24 , wherein about 550 to about 650 milligrams of 4-hydroxyisoleucine is administered to the athlete on a daily basis.
26. The regimen of claim 24 , wherein about 9 grams to about 11 grams of creatine monohydrate is administered to the athlete on a daily basis.
27. The regimen of claim 24 , wherein not more than 50 milligrams 4-hydroxyisoleucine per kilogram of the athlete's body weight is administered to the athlete on a daily basis.
28. The regimen of claim 24 , wherein about 1 milligram to about 30 milligrams 4-hydroxyisoleucine per kilogram of the athlete's body weight is administered to the athlete on a daily basis.