IP Library Granted Patent US 7,368,480
Granted Patent B2
US 7,368,480 · App. 10/427,768 · Granted May 6, 2008

Methods and compositions with trans-clomiphene

Assignee: Repros Therapeutics Inc.
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Quick Facts
Patent No.
US 7,368,480
App. No.
10/427,768
Granted
May 6, 2008
Kind
B2
Abstract

The present invention relates to the use of compositions comprising trans-clomiphene for treating men with hypogonadism. The invention is also directed to methods for treating males with hypogonadism. The present invention is also directed to methods of decreasing cholesterol levels.

Claims (7)

1. A method of decreasing cholesterol levels in a human, the method comprising administering to a human in need thereof, an effective amount of a composition comprising about 100% w/w of active ingredients of trans-clomiphene or pharmaceutically acceptable salts or solvates thereof and optionally one or more pharmaceutically acceptable diluents, adjuvants, carriers or exicipients.

2. The method of claim 1 where the human is a male.

3. The method of claim 1 where the human is a female.

4. The method of claim 1 , wherein the composition is administered in a dosage of 1-200 mg of trans-clomiphene per day.

5. The method of claim 4 , wherein the composition is administered in a dosage of about 50 mg of trans-clomiphene per day.

6. The method of claim 4 , wherein the composition is administered in a dosage of 1.5 mg/kg of trans-clomiphene per day.

7. The method of claim 1 wherein the composition is provided in capsule form.

Assignments (3)
CHANGE OF NAME Recorded Nov 30, 2006
From: ZONAGEN, INC.
To: REPROS THERAPEUTICS INC.
Reel/Frame 018573/0121 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ZONAGEN, INC. 2408 TIMBERLOCH PLACE, B-4 HOUSTON, TEXAS 77380 PREVIOUSLY RECORDED ON REEL 014950 FRAME 0531. ASSIGNOR(S) HEREBY CONFIRMS THE ZONAGEN, INC. 2408 TIMBERLOCH PLACE, B-4 THE WOODLANDS, TEXAS 77380. Recorded Oct 7, 2004
From: PODOLSKI, JOSEPH S.; WEIHLE, RONALD
To: ZONAGEN, INC.
Reel/Frame 015224/0611 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 2, 2004
From: PODOLSKI, JOSEPH S.; WEIHLE, RONALD
To: ZONAGEN, INC.
Reel/Frame 014950/0531 →
Continuity (3)
Continuation In Part PCTUS022152400 · Jul 9, 2002
Provisional Application 6030431300 · Jul 9, 2001
Related Publication 20040097597A1 · May 20, 2004