Virulence of Streptococci
View Patent ↗The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of a Streptococcus comprising modifying a genomic fragment of Streptococcus wherein the genomic fragment comprises at least a functional part of a fragment identifiable by hybridization in Streptococcus suis to a nucleic acid or fragment thereof as shown in FIG. 5 .
1. A method for modifying a Streptococcus suis , said method comprising:
introducing a nucleic acid sequence encoding a virulence factor into the Streptococcus suis , said nucleic acid sequence selected from the group consisting of SEQ ID NO:14, and a conservatively substituted variant of SEQ ID NO:14, wherein said conservatively substituted variant encodes a virulence factor having the virulence-modulating activity of the virulence factor encoded by SEQ ID NO:14.
2. A method of modulating virulence of a Streptococcus suis comprising:
introducing into said S. suis a nucleotide sequence comprising SEQ ID NO:14 or a conservatively substituted variant of SEQ ID NO:14, wherein said conservatively substituted variant encodes a virulence factor having the virulence-modulating activity of the virulence factor encoded by SEQ ID NO:14.