Use of cyclohexenone derivatives in the manufacture of a medicament for treating diabetic complications
A preventive and/or therapeutic agent for diabetes complications, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1): wherein, R 1 , R 2 and R 3 each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C 10-28 alkylene or alkenylene group. The cyclohexenone long-chain alcoholic derivative of the present invention significantly suppresses a reduction in a peripheral nerve conduction rate and alleviates the hypofunction of the bladder so that it is useful as a preventive and/or therapeutic agent for diabetes complications, particularly, for diabetic neuropathy.
1. A method for treating diabetic complications, comprising:
administering to a diabetic patient suffering from lowering in a stimulus conduction rate of a peripheral nerve an effective amount of a composition comprising:
a cyclohexenone long-chain alcoholic compound represented by the following formula (1):
wherein
R 1 , R 2 and R 3 each independently represent a hydrogen atom or a methyl group, and
X represents a linear or branched C 10-28 alkylene group;
or a salt of the compound of formula (1), wherein the diabetic complications are induced by the lowering in a stimulus conduction rate of a peripheral nerve, and wherein said diabetic complications comprise diabetic neuropathy.
2. The method of claim 1 , wherein a dosage of the compound of formula (1) ranging from 0.01 to 1,000 mg per day is administered to a human subject.
3. The method of claim 1 , wherein R 1 , R 2 and R 3 are hydrogen.
4. The method of claim 1 , wherein at least one of R 1 , R 2 and R 3 is a methyl group.
5. The method of claim 1 , wherein at least two of R 1 , R 2 and R 3 are methyl groups.
6. The method of claim 1 , wherein R 1 , R 2 and R 3 are methyl groups.
7. The method of claim 1 , wherein X represents a linear C 10-28 alkylene group.
8. The method of claim 1 , wherein X represents a branched C 10-28 alkylene group.
9. The method of claim 1 , wherein at least one of R 1 , R 2 or R 3 is a methyl group and X is a linear C 10 -C 18 alkylene group in the compound of formula (1).
10. The method of claim 1 , wherein said compound is administered orally.
11. The method of claim 1 , wherein said compound is administered parenterally.