Polymeric bioresorbable composites containing an amorphous calcium phosphate polymer ceramic for bone repair and replacement
A bioresorbable composite of a non-crystalline calcium phosphate ceramic synthesized within an encapsulating microspheres of bioresorbable polymeric material for use in bone repair and replacement is provided. Also provides are methods for producing these composites as well as porous, 3-dimensional scaffold produced by sintering together microspheres of this bioresorbable composite.
1. A bioresorbable composite comprising a bioresorbable polymeric microsphere containing approximately 28 weight percent or more of a non-crystalline calcium phosphate ceramic relative to the mass of the entire composite, wherein said non-crystalline calcium phosphate ceramic is synthesized within the encapsulating microsphere of bioresorbable polymeric material.
2. A method for producing the bioresorbable composite of claim 1 comprising synthesizing the calcium phosphate ceramic within the encapsulating microspheres of the bioresorbable material.
3. A porous, 3-dimensional scaffold comprising microspheres of the bioresorbable composite of claim 1 .
4. The bioresorbable composite of claim 1 , wherein the calcium phosphate is characterized by an x-ray diffraction pattern indicative of an amorphous or poorly crystalline material.
5. The bioresorbable composite of claim 1 , wherein the calcium phosphate ceramic is characterized as having a stoichiometry approximately that of hydroxyapatite, calcium phosphate, tricalcium phosphate, tetracalcium phosphate, bone apatite, or any combination thereof.
6. The bioresorbable composite of claim 1 , wherein the calcium phosphate is characterized as having a stoichiometry approximately that of bone apatite.
7. The bioresorbable composite of claim 1 , wherein the calcium phosphate additionally comprises carbonated calcium phosphate.
8. The bioresorbable composite of claim 1 , wherein the bioresorbable polymeric material comprises a polylactic acid, a polyglycolic acid, a poly(lactic acid—glycolic acid), a polyanhydride, a poly(phosphazene), a poly(orthoester), a poly(caprolactone), a polyhydroxybutyrate, a polyanhydroideco-imide, a polypropylene fumarate, a polydiaxonane, or a polyurethane polymer, or any copolymer or mixture thereof.
9. The bioresorbable composite of claim 1 , wherein the bioresorbable polymeric material comprises a polylactic acid, a polyglycolic acid, a poly(lactic acid—glycolic acid) polymer or any copolymer or mixture thereof.
10. The bioresorbable composite of claim 1 , wherein the bioresorbable composite is in the form of microspheres characterized as having a diameter between about 100 and about 250 microns.
11. A bioresorbable composite comprising a bioresorbable polymeric microsphere containing approximately 28 weight percent or more of a non-crystalline, poorly crystalline, or amorphous calcium phosphate ceramic relative to the mass of the entire composite.
12. The bioresorbable composite of claim 11 , wherein the calcium phosphate is characterized by an x-ray diffraction pattern indicative of an amorphous or poorly crystalline material.
13. The bioresorbable composite of claim 11 , wherein the calcium phosphate ceramic is characterized as having a stoichiometry approximately that of hydroxyapatite, calcium phosphate, tricalcium phosphate, tetracalcium phosphate, bone apatite, or any combination thereof.
14. The bioresorbable composite of claim 11 , wherein the calcium phosphate is characterized as having a stoichiometry approximately that of bone apatite.
15. The bioresorbable composite of claim 11 , wherein the calcium phosphate additionally comprises carbonated calcium phosphate.
16. The bioresorbable composite of claim 11 , wherein the bioresorbable polymeric material comprises a polylactic acid, a polyglycolic acid, a poly(lactic acid—glycolic acid), a polyanhydride, a poly(phosphazene), a poly(orthoester), a poly(caprolactone), a polyhydroxybutyrate, a polyanhydroideco-imide, a polypropylene fumarate, a polydiaxonane, or a polyurethane polymer, or any copolymer or mixture thereof.
17. The bioresorbable composite of claim 11 , wherein the bioresorbable polymeric material comprises a polylactic acid, a polyglycolic acid, a poly(lactic acid—glycolic acid) polymer or any copolymer or mixture thereof.
18. The bioresorbable composite of claim 11 , wherein the bioresorbable composite is in the form of microspheres characterized as having a diameter between about 100 and about 250 microns.
19. The method of claim 2 wherein the bioresorbable microspheres are formed by emulsification.
20. The scaffold of claim 3 wherein the majority of pores within the scaffold are at least 100 microns in diameter.
21. The scaffold of claim 3 wherein the scaffold is suitable for tissue repair and/or replacement applications.
22. The scaffold of claim 21 wherein the tissue is bone.
23. A porous, 3-dimensional scaffold comprising microspheres of the bioresorbable composite of claim 11 .
24. The scaffold of claim 23 wherein the majority of pores within the scaffold are at least 100 microns in diameter.
25. The scaffold of claim 23 wherein the scaffold is suitable for tissue repair and/or replacement applications.
26. The scaffold of claim 25 wherein the tissue is bone.