Granted Patent
B2
US 7,282,556 · App. 10/473,495 · Granted Oct 16, 2007
Polynucleotides and polypeptides relating to the modulation of SIRPα-CD47
Assignee:
Emory University
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Abstract
Polypeptides that can modulate SIRPα-CD47 functions and methods of use of the polypeptides are presented. In addition, polynucleotides that encode the polypeptides referred to above are presented. Further, pharmaceutical compositions to treat conditions are presented.
Claims (3)
1. An isolated polypeptide, consisting of an amino acid sequence selected from: the amino acid sequence set forth in SEQ ID NO:2; the amino acid sequence set forth in SEQ ID NO:4; and the amino acid sequence set forth in SEQ ID NO:6.
2. A fusion polypeptide consisting of a heterologous polypeptide and the polypeptide of claim 1 .
3. The isolated polypeptide of claim 1 , wherein the polypeptide inhibits the interaction of SIRPα with CD47.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Jul 17, 2008
From: EMORY UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 021254/0482 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 23, 2005
From: PARKOS, MR. CHARLES A.
To: EMORY UNIVERSITY
Reel/Frame 016047/0258 →
Continuity (2)
Provisional Application
6029105000
· May 15, 2001