Disinfecting oral rinse compositions and process for using the same
View Patent ↗This invention relates generally to compositions and methods useful for oral hygiene rinses, and more specifically to oral rinses in which the antimicrobial activity of chlorous acid is supplemented by that of lactic acid as one of a combination of antimicrobial acids, preferably acids which serve to partially convert chlorite ion to chlorous acid.
1. A palatable antimicrobial oral hygiene rinse composition comprising water and a chlorite salt in combination with an acid combination comprising lactic acid and at least one additional protic acid, said acid combination producing in combination with said chlorite salt an in situ effective amount of chlorous acid in said rinse composition at a pH ranging from about 2.5 to 3.5, said lactic acid comprising 2% to 12% by weight of said acid combination, wherein said additional acid is selected from the group consisting of citric, fumaric, glycolic, malic, tartaric acid, succinic, adipic, mandelic, and mixtures thereof.
2. The composition according to claim 1 wherein said chlorite salt ranges from about 0.05% to about 0.5% by weight of said composition.
3. The composition according to claim 1 wherein said chlorite salt is sodium chlorite or potassium chlorite.
4. The composition according to claim 1 wherein said lactic acid is prepared in situ by the stoichiometric combination of a lactate salt and a protic acid having a pK a of less than lactic acid and/or an excess of a protic acid which has a pK a which is greater than lactic acid.
5. The composition according to claim 1 wherein said composition further comprises at least one additive agent selected from the group consisting of surface active agents, colorants, humectants, flavorants, sweeteners, fluoride ion sources, calcium sources and thickeners.
6. A method of reducing the number of microorganisms in the mouth cavity of a mammal, said method comprising exposing said mouth cavity to a composition according to claim 1 for a period of time effective to reduce the number of microorganisms in said mouth cavity.
7. A method of reducing the number of microorganisms in the mouth cavity of a mammal, said method comprising exposing said mouth cavity to a composition according to claim 2 for a period of time effective to reduce the number of microorganisms in said mouth cavity wherein said composition comprises a fluoride ion source or a calcium source.
8. A method of reducing the number of microorganisms in the mouth cavity of a mammal, said method comprising exposing said mouth cavity to a composition according to claim 2 for a period of time effective to reduce the number of microorganisms in said mouth cavity.
9. A method of reducing the number of microorganisms in the mouth cavity of a mammal, said method comprising exposing said mouth cavity to a composition according to claim 3 for a period of time effective to reduce the number of microorganisms in said mouth cavity.
10. A method of reducing the number of microorganisms in the mouth cavity of a mammal, said method comprising exposing said mouth cavity to a composition according to claim 4 for a period of time effective to reduce the number of microorganisms in said mouth cavity.
11. A method of reducing the number of microorganisms in the mouth cavity of a mammal, said method comprising exposing said mouth cavity to a composition according to claim 5 for a period of time effective to reduce the number of microorganisms in said mouth cavity.
12. A method of reducing the number of microorganisms in the mouth cavity of a mammal, said method comprising exposing said mouth cavity to a composition according to claim 5 wherein said composition comprises a fluoride ion source or a calcium source for a period of time effective to reduce the number of microorganisms in said mouth cavity.
13. The composition according to claim 1 wherein said acid is an α-hydroxy acid selected from the group consisting of citric, glycolic, malic, tartaric, mandelic and mixtures thereof.
14. A method of reducing the number of microorganisms in the mouth cavity of a mammal, said method comprising exposing said mouth cavity to a composition according to claim 13 for a period of time effective to reduce the number of microorganisms in said mouth cavity.