Method for treating medical devices using glycerol and an antimicrobial agent
A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices depending on the types of infections related to each device. The combination of different antimicrobial substances has a synergistic effect against certain bacteria and fungi. An antimicrobial agent can be used to treat a non-metallic medical device by mixing the antimicrobial agent with an acid solution and glycerol and exposing the non-metallic medical device to the resulting mixture such that an enough of the antimicrobial agent binds to a portion of the non-metallic medical device to inhibit the growth of bacterial and fungal organisms.
1. A method of treating a non-metallic medical device with an antimicrobial agent comprising the steps of:
mixing at least an antimicrobial agent, an acid solution comprising formic acid, potassium chloride and phosphoric acid, and glycerol to form an antimicrobial composition; and
applying the antimicrobial composition to at least a portion of the non-metallic medical device under conditions wherein an effective concentration of the antimicrobial composition binds to the non-metallic medical device.
2. The method according to claim 1 , wherein the ratio of formic acid to potassium chloride to phosphoric acid is about 30 ml:400 mg:3 ml.
3. The method according to claim 1 , wherein the ratio of formic acid to potassium chloride to phosphoric acid to Glycerol is about 30 ml:400 mg: 3 ml:5 ml.
4. The method according to claim 1 , wherein the antimicrobial agent comprises chlorhexidine and chloroxylenol.
5. An implantable medical device comprising:
a body with one or more non-metallic surfaces, wherein at least one of the one or more non-metallic surfaces has been treated with a solution comprising an effective concentration of antimicrobial agent, acid solution, wherein said acid solution is comprised of short chain monocarboxylic acid and ortho-phosphoric acid, and glycerol.
6. The device of claim 5 , wherein at least one of the one or more non-metallic surfaces comprises a biomaterial.
7. The device of claim 6 , wherein the biomaterial is human tissue, non-human tissue, or any combination thereof.
8. The device of claim 7 , wherein the human tissue is a small intestinal submucosa or skin.
9. The device of claim 7 , wherein the non-human tissue is a small intestinal submucosa or skin.
10. The device of claim 7 , wherein the combination of human tissue and non-human tissue is a small intestinal submucosa or skin.
11. A method of treating a non-metallic medical device with an antimicrobial agent comprising the steps of:
mixing at least an antimicrobial agent, an acid solution comprising formic acid, potassium chloride and phosphoric acid, and glycerol to form an antimicrobial composition;
applying the antimicrobial composition to at least a portion of the non-metallic medical device under conditions wherein an effective concentration of the antimicrobial composition binds to the non-metallic medical device; and
wherein the non-metallic medical device comprises a biomaterial.
12. The method of claim 11 , wherein the biomaterial is human tissue, non-human tissue, or any combination thereof.
13. The method according to claim 12 , wherein the human tissue is a small intestinal submucosa or skin.
14. The method according to claim 12 , wherein the non-human tissue is a small intestinal submucosa or skin.
15. The method according to claim 12 , wherein the combination of human tissue and non-human tissue is a small intestinal submucosa or skin.
16. The method according to claim 11 , wherein the ratio of formic acid to potassium chloride to phosphoric acid is about 20 ml:20 mg:1.4 ml.
17. The method according to claim 11 , wherein the ratio of formic acid to potassium chloride to phosphoric acid to glycerol is about 20 ml:20 mg:1.4 ml:1.9 ml.
18. The method according to claim 11 , wherein the antimicrobial agent comprises minocycline and rifampin.
19. The method according to claim 11 , wherein the biomaterial is immersed in the antimicrobial composition for about 30 minutes.
20. The method according to claim 19 , wherein the biomaterial is immersed in the antimicrobial composition in the dark.
21. The method according to claim 11 , wherein the antimicrobial composition has a temperature of about 5° C.
22. An implantable medical device comprising:
a body with at least one surface comprising a biomaterial treated with a solution comprising formic acid, potassium chloride and phosphoric acid, glycerol, and an antimicrobial agent, wherein an effective concentration of the antimicrobial agent coat said at least one surface comprising a biomaterial.
23. The device of claim 22 , wherein the antimicrobial agent is selected from the group consisting of: chlorhexidine and methylisothiazolone; chlorhexidine and α-terpineol; thymol and chloroxylenol; thymol and methylisothiazolone; chlorhexidine and cetylpyridinium chloride; chlorhexidine and chloroxylenol; chlorhexidine, methylisothiazolone and thymol; methylisothiazolone and α-terpineol; minocycline and rifampin; and chlorhexidine, methylisothiazolone and α-terpineol.
24. The device of claim 22 , wherein the antimicrobial agent is comprised of a minocycline and rifampin.
25. The device of claim 22 , wherein the biomaterial is human tissue, non-human tissue, or any combination thereof.
26. The device of claim 25 , wherein the human tissue is a small intestinal submucosa or skin.
27. The device of claim 25 , wherein the non-human tissue is a small intestinal submucosa or skin.
28. The device of claim 25 , wherein the combination of human tissue and non-human tissue is a small intestinal submucosa or skin.