IP Library › Granted Patent US 7,238,663
Granted Patent B2
US 7,238,663 · App. 10/486,333 · Granted Jul 3, 2007

Pre-mixes of GLP-1 and basal insulin

Assignee: Eli Lilly and Company
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Quick Facts
Patent No.
US 7,238,663
App. No.
10/486,333
Granted
Jul 3, 2007
Kind
B2
Abstract

The present invention encompasses pre-mixed formulations comprising a GLP-1 polypeptide and a basal insulin.

Claims (3)

1. A pre-mixed formulation comprising a GLP-1 compound and an acylated basal insulin wherein the GLP-1 compound is Arg 34 Lys 26 -(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-37) and the acylated basal insulin is NεB29-tetradecanoyl des(B30) human insulin.

2. A process of preparing the pre-mixed formulation of claim 1 , wherein the process comprises the steps of mixing said GLP-1 compound with said basal insulin in an aqueous medium.

3. A method of treating a condition selected from the group consisting of non-insulin dependent diabetes and insulin dependent diabetes comprising administering an effective amount of a pre-mixed formulation of claim 1 to a patient in need thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 9, 2004
From: DEFELIPPIS, MICHAEL ROSARIO; DIMARCHI, RICHARD DENNIS; NG, KINGMAN
To: ELI LILLY AND COMPANY
Reel/Frame 015505/0342 →
Continuity (4)
Provisional Application 6038606100 · Jun 4, 2002
Provisional Application 6038526600 · May 31, 2002
Provisional Application 6031546000 · Aug 28, 2001
Related Publication 20040235710A1 · Nov 25, 2004