Crystals of taxane derivative and process for their production
A crystal of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-hydroxypropionate, which has characteristic peaks at diffraction angles (2θ) of 6.2°, 10.3°, 10.7°, 11.4°, and 12.0° in a powder X-ray diffraction pattern, and a method for preparing the aforementioned crystal, which comprises the step of performing crystallization by using an organic solvent selected from the group consisting of a ketone type solvent, a nitrile type solvent, and a mixture thereof, or a mixture of said organic solvent and water.
1. A crystal of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S) -3-(tert-butoxycarbonylamino)-3 -(3 -fluoro-2-pyridyl)-2-hydroxypropionate, which has characteristic peaks at diffraction angles (2θ) of 6.2°, 10.3°, 10.7°, 11.4°, and 12.0° in a powder X-ray diffraction pattern.
2. A method for preparing the crystal according to claim 1 , which comprises performing crystallization by using an organic solvent selected from the group consisting of a ketone type solvent, a nitrile type solvent, and a mixture thereof, or a mixture of said organic solvent and water.
3. The method according to claim 2 , wherein the organic solvent is an organic solvent selected from the group consisting of acetone, acetonitrile, and a mixture thereof.
4. The method according to claim 2 , wherein the crystallization is performed by using a mixture of acetone and water or a mixture of acetonitrile and water.
5. The method according to claim 4 , wherein the mixture of acetone and water or the mixture of acetonitrile and water has a water content of 40 to 50% by weight.
6. The method according to claim 2 , which comprises drying the crystals obtained by the crystallization at a temperature of from 30 to 60° C.
7. The method according to claim 3 , which comprises drying the crystals obtained by the crystallization at a temperature of from 30 to 60° C.
8. The method according to claim 4 , which comprises drying the crystals obtained by the crystallization at a temperature of from 30 to 60° C.
9. The method according to claim 5 , which comprises drying the crystals obtained by the crystallization at a temperature of from 30 to 60° C.