Polypeptides of
The present invention relates to polypeptides, more particularly polypeptides of Moraxella ( Branhamella ) catarrhalis which may be used to prevent, diagnose and/or treat Moraxella ( Branhamella ) catarrhalis infection.
1. An isolated polypeptide consisting of an amino acid sequence at least 90% identical to the amino acid sequence set forth as SEQ ID NO:2, wherein the polypeptide is capable of eliciting an antibody that specifically bonds to a protein consisting of the amino acid sequence set forth as SEQ ID NO:2, and wherein the polypeptide is capable of eliciting an immune response against Moraxella catarrhalis.
2. The isolated polypeptide according to claim 1 consisting of an amino acid sequence at least 95% identical to the amino sequence set forth as SEQ ID NO:2.
3. The polypeptide according to claim 1 consisting of an amino acid sequence at least 99% identical to the amino acid sequence set forth as SEQ ID NO:2.
4. The polypeptide according to claim 1 wherein the polypeptide consists of an amino sequence identical to the sequence set forth as SEQ ID NO:2.
5. An isolated polypeptide consisting of an amino acid sequence at least 95% identical to the amino acid sequence set forth as SEQ ID NO:2 from which the signal peptide consisting of the amino acid sequence set forth as SEQ ID NO:13 id deleted, where the polypeptide is capable of eliciting an antibody that specifically binds to a protein consisting of the amino acid sequence set forth as SEQ ID NO:2, and wherein the polypeptide is capable of an immune response against Moraxella catarrhalis.
6. The polypeptide according to claim 5 consisting of an amino acid sequence at least 99% identical to the amino acid sequence set forth as SEQ ID NO:2 from which the signal peptide sequence is deleted.
7. The polypeptide according to claim 5 consisting of the amino acid sequence set forth as SEQ ID NO:2 from which the signal peptide sequence is deleted.
8. An isolated polypeptide consisting of the amino acid sequence set forth as SEQ ID NO:2 from which the N-terminal valine residue is deleted, wherein the polypeptide is capable of eliciting an antibody that specifically binds to a protein consisting of the amino acid sequence ser forth as SEQ ID NO:2, and wherein the polypeptide is capable of eliciting an immune response against Moraxella catarrhalis.
9. A pharmaceutical composition comprising a polypeptide according to any one of claims 1 , 2 , and 3 - 8 and a pharmaceutically acceptable carrier, diluent or adjuvant.
10. A pharmaceutical composition comprising a polypeptide according to any one of claims 1 , 2 , and 3 - 8 and a liposome.
11. A kit comprising a polypeptide according to either claim 4 or claim 7 for detection or diagnosis of Moraxella catarrhalis infection.