Medicament for the treatment of viral skin and tumour diseases
The invention relates to a medicament containing a compound of general formula (1), where R 1 =independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C 11 -C 21 alkyl, alkylene or alkynyl group, preferably a C 11 -C 15 alkyl, alkylene or alkynyl group, particularly a C 11 -C 13 alkyl, alkylene or alkynyl group, most preferably a C 13 alkyl group, R2=independently, a straight or branched C 1 -C 8 alkyl, alkylene or alkynyl group, preferably a C 1 -C 6 alkyl, alkylene or alkynyl group, in particular a C 2 -C 4 alkyl, alkylene or alkynyl group, most preferably a C 3 alkyl group, a —[CH 2 —(CH 2 ) m —O] n H group with n=1 to 10, preferably n=1 to 5, m=1 to 5, preferably m=1 to 3, a —CH 2 —[CH—(OH)] p [CH 2 —(R 3 )]— group, where R 3 =independent H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumor diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.
1. A pharmaceutical which comprises, as the pharmaceutically active compound, isopropyl myristate and a mixture of catechols comprising 4-15% (w/w) of (−)-epicatechol, 2-20% (w/w) of (−)-epicatechol gallate, 3-15% (w/w) of (−)-epigallocatechol, 40-75% (w/w) of (−)-epigallocatechol gallate, 0.1-1% (w/w) of (+)-gallocatechol and 1-10% (w/w) of (−)-gallocatechol gallate, and wherein the pharmaceutical comprises at least 5-50% (w/w) of isopropyl myristate.
2. A pharmaceutical as claimed in claim 1 , characterized in that the pharmaceutical also comprises one or more additional pharmaceutical active compounds as a combination preparation for use which is simultaneous, separate or staggered in time.
3. A pharmaceutical as claimed in claim 2 , characterized in that the additional pharmaceutical active compound is amphiphilic.
4. A pharmaceutical as claimed in claim 1 , characterized in that said mixture of catechols comprises 10.8% (w/w) of (−)-epicatechol, 6.5% (w/w) of (−)-epicatechol gallate, 9.2% (w/w) of (−)-epigallocatechol, 54.8% (w/w) of (−)-epigallocatechol gallate and/or 4.0% (w/w) of (−)-gallocatechol gallate.
5. A pharmaceutical as claimed in claim 1 , characterized in that said catechols are isolated from a tea extract.
6. A pharmaceutical as claimed in claim 1 , characterized in that the formulation comprises 1-30% (w/w) of said mixture of catechols and at least 10-50% (w/w) of said isopropyl myristate.
7. A pharmaceutical as claimed in claim 1 , which comprises further additives and/or auxiliary substances.
8. A pharmaceutical as claimed in claim 7 , characterized in that the additives and/or auxiliary substances are hydrophobic and are preferably selected from petroleum jelly, wax, oleyl alcohol, propylene glycol monostearate and propylene glycol monopalmitostearate.
9. A pharmaceutical which comprises 35% (w/w) of isopropyl myristate, 15% (w/w) of a mixture of catechols comprising 4-15% (w/w) of (−)-epicatechol, 2-20% (w/w) of (−)-epicatechol gallate, 3-15% (w/w) of (−)-epigallocatechol, 40-75% (w/w) of (−)-epigallocatechol gallate, 0.1-1% (w/w) of (+)-gallocatechol and 1-10% (w/w) of (−)-gallocatechol gallate, 24.5% (w/w) of petroleum jelly, 20% (w/w) of wax, 5% (w/w) of propylene glycol mono stearate or propylene glycol monopalmitostearate and 0.5% (w/w) of oleyl alcohol.
10. A method of treating a papilloma virus-induced skin disease or benign tumor disease in a patient, said method comprising administering to a patient a pharmaceutical as claimed in claim 1 .
11. The method as claimed in claim 10 , characterized in that the papilloma virus-induced skin or tumor disease is caused by HPV 1, 2, 3, 4, 5, 6, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19-29, 31, 32, 34, 36-38, 46-50, 56 or 58.
12. The method as claimed in claim 10 , characterized in that the papilloma virus-induced skin diseases are warts or genital warts and the papilloma virus-induced benign tumors are of the skin and/or mucosa.
13. The method as claimed in claim 10 , characterized in that the pharmaceutical is applied topically.
14. The pharmaceutical as claimed in claim 1 , wherein said mixture of catechols comprises 5-7% (w/w) of said (−)-epicatechol gallate.
15. The pharmaceutical as claimed in claim 1 , wherein said mixture of catechols comprises 0.1-0.6% (w/w) of said (+)-gallocatechol.
16. The pharmaceutical as claimed in claim 1 , wherein said mixture of catechols comprises 1-5% (w/w) of said (−)-gallocatechol gallate.
17. The pharmaceutical as claimed in claim 1 , wherein said pharmaceutical comprises at least 10-50% (w/w) of said isopropyl myristate.
18. The pharmaceutical as claimed in claim 17 , wherein said pharmaceutical comprises at least 25-50% (w/w) of said isopropyl myristate.
19. The pharmaceutical as claimed in claim 18 , wherein said pharmaceutical comprises at least 35-50% (w/w) of said isopropyl myristate.
20. The pharmaceutical as claimed in claim 6 , wherein said formulation comprises 2-20% (w/w) of said mixture of catechols.
21. The pharmaceutical as claimed in claim 20 , wherein said formulation comprises 15-18% (w/w) of said mixture of catechols.
22. The pharmaceutical as claimed in claim 6 , wherein said formulation comprises at least 25-60% (w/w) of said isopropyl myristate.
23. The pharmaceutical as claimed in claim 22 , wherein said formulation comprises at least 35-50% (w/w) of said isopropyl myristate.
24. The method as claimed in claim 12 , wherein said “papilloma virus-induced” benign tumors of the skin and/or mucosa are verrucae plantares, verrucae vulgares, verrucae planae juveniles, epidermodysplasia verruciformis, Condylomata acuminata, Condylomata plana, bowenoid papulosis, papillomas on the larynx and oral mucosa or focal epithelial hyperplasia.
25. The method as claimed in claim 13 , wherein said pharmaceutical is applied genitally or vaginally.