4-(Oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]-nonane derivatives, preparation and therapeutic use thereof
View Patent ↗The invention relates to compounds of the Formula I, to pharmaceutical compositions comprising them, and to the method of use thereof in the treatment or prevention of disorders linked to a dysfunction of the nicotinic receptors.
1. A compound of the formula (I)
in which R represents a (C 3 –C 6 )cycloalkyl group or a phenyl group which is optionally substituted by one or more groups selected from a halogen atom, a (C 1 –C 6 ) alkyl, (C 1 –C 6 )alkoxy, nitro, amino, di(C 1 –C 3 )alkylamino, trifluoromethoxy, trifluoromethyl, cyano, hydroxyl or methylenedioxy group, or a piperid-1-yl or 4-morpholinyl or pyrrolidin-1-yl or azetidin-1-yl or azepin-1-yl or pyridyl or piperazinyl or thienyl or pyrazinyl or furyl or benzofuryl or benzothienyl or indolyl or pyrimidinyl or isoxazolyl or phenoxazinyl or dibenzofuryl or dibenzothienyl or pyrrolyl or naphthyl group, each of which groups may optionally be substituted by one or more groups selected from a halogen atom or a (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, trifluoromethoxy, trifluoromethyl, nitro, cyano, hydroxyl, amino, (C 1 –C 3 )dialkylamino or (C 3 –C 8 )cycloalkylamino group, in the form of a base or an addition salt with an acid.
2. The compound according to claim 1 , wherein R represents a phenyl group which is optionally substituted by one or more halogen atoms or by one or more (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, nitro, amino, trifluoromethoxy, trifluoromethyl, cyano, hydroxyl or methylenedioxy groups, or a pyridyl group or a thienyl group.
3. A method for the treatment of a disease selected from the group consisting of schizophrenia, Alzheimer's disease, Parkinson's disease, Down's syndrome, Korsakoff's alcoholic syndrome, vascular dementia, depression, anxiety, panic attack and obsessive-compulsive behavior, which comprises administering to a patient in need of such treatment an effective amount of a compound according to claim 1 .
4. A pharmaceutical composition comprising a compound according to claim 1 in combination with an excipient.
5. A method for the treatment of a disease selected from the group consisting of schizophrenia, Alzheimer's disease, Parkinson's disease, Down's syndrome, Korsakoff's alcoholic syndrome, vascular dementia, depression, anxiety, panic attack and obsessive-compulsive behavior, which comprises administering to a patient in need of such treatment an effective amount of a compound according to claim 2 .
6. A pharmaceutical composition that comprises a compound according to claim 2 in combination with an excipient.