4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo-[3.2.2]nonane derivatives, preparation and therapeutic use thereof
View Patent ↗The invention relates to compounds of the Formula I, to pharmaceutical compositions comprising them, and to the method of use thereof in the treatment or prevention of disorders associated with a dysfunction of the nicotinic receptors.
1. A compound of the formula (I)
in which R represents a (C 1 –C 6 )cycloalkyl group or a phenyl group optionally substituted with one or more groups chosen from a halogen atom, a (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, nitro, amino, di(C 1 –C 6 )alkylamino, trifluoromethoxy, trifluoromnethyl, cyano, hydroxyl or methylenedioxy group or a 1-piperidyl, 4-morpholinyl, 1-pyrrolidinyl, 1-azetidinyl, 1-azepinyl, pyridyl, thienyl, pyrazinyl, furyl, benzofmyl, beuzothienyl, indolyl, pyrimidinyl, isoxazolyl, phenoxzinyl, phenoxathienyl, dibeuzofuryl, dibeuzothienyl, pyrrolyl or naphthyl group, each of these groups possibly being substituted with one or more groups chosen from a halogen atom and a (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, trifluoromethoxy, trifluoromethyl, nitro, cyano, hydroxyl, amino, di(C 1 –C 3 )alkylamino or (C 3 –C 8 )cycloalkylamino group, in base form or in the form of an acid-addition salt.
2. The compound according to claim 1 wherein R. represents a phenyl group substituted with one or more halogen atoms or with one or more (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, nitro, amino, trifluoromethoxy, trifluoromethyl, cyano, hydroxyl or methylenedioxy groups, or a pyridyl group, or a thienyl group optionally substituted with a halogen atom, or a pyrazinyl group.
3. A pharmaceutical composition containing a compound according to claim 1 combined with an excipient.
4. A pharmaceutical composition containing a compound according to claim 2 combined with an excipient.