IP Library Granted Patent US 7,310,150
Granted Patent B2
US 7,310,150 · App. 10/501,268 · Granted Dec 18, 2007

Apparatus and method for low coherence ranging

Assignee: The General Hospital Corporation
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Quick Facts
Patent No.
US 7,310,150
App. No.
10/501,268
Granted
Dec 18, 2007
Kind
B2
Abstract

A system, apparatus and method for performing low coherence ranging of a sample with high transverse resolution and large depth of focus can be provided. For example, an optical ranging system including a light source can be used. Certain exemplary arrangement can be provided, e.g., a first arrangement for directing light from the light source to the sample, a second arrangement for directing reflected light from the sample to a detector, at least one detector, and a third arrangement for processing light data received by the detector and which generates an image can be utilized. Further, for example, an optical element can be provided which can have a transverse resolution defined as .Δris less than or equal to about μ5 m, and a depth of focus Δz of at least about 50 μm.

Claims (81)

1. An apparatus for imaging at least a portion of a sample, comprising:

a first interferometric arrangement providing an electro-magnetic radiation; and

a second arrangement configured to receive the electro-magnetic radiation, and configured to generate a resultant electro-magnetic intensity distribution,

wherein, along a particular direction, the intensity distribution is approximately constant for at least a predetermined distance, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the predetermined distance at which the intensity distribution is approximately constant.

2. The apparatus according to claim 1 , wherein the second arrangement is an optical arrangement which is configured to optically image the sample.

3. The apparatus according to claim 1 , wherein the second arrangement is an axicon lens.

4. The apparatus according to claim 1 , wherein the second arrangement is a defractive optical element.

5. The apparatus according to claim 1 , wherein the second arrangement is an annulus.

6. The apparatus according to claim 1 , wherein the second arrangement includes a combination of a diffractive element and a lens.

7. The apparatus according to claim 1 , wherein the second arrangement includes at least one of an apodized lens or a diffractive element.

8. The apparatus according to claim 1 , wherein the intensity distribution is a Bessel beam.

9. The apparatus according to claim 1 , further comprising a third arrangement adapted to cooperate with the second arrangement so as to translate at least one of the intensity distribution and the sample.

10. The apparatus according to claim 9 , wherein the translation of the at least one of the intensity distribution and the sample produces an image which has 2 or more dimensions.

11. The apparatus according to claim 1 , wherein the intensity distribution having a transverse resolution of a full width at half maximum is less than 10 μm.

12. The apparatus according to claim 1 , wherein the predetermined distance is at least 50 μm.

13. The apparatus according to claim 1 , wherein at least a portion of the intensity distribution includes a non-Gaussian distribution.

14. The apparatus according to claim 1 , further comprising a fourth arrangement configured to received information that is associated with the intensity distribution, and display an image based on the received information.

15. An apparatus for imaging at least a portion of a sample, comprising:

a first interferometric arrangement providing an electro-magnetic radiation; and

a second arrangement configured to receive the electro-magnetic radiation, and configured to generate a resultant electro-magnetic intensity distribution,

wherein, along a particular direction, widths of at least two sections of the intensity distribution are approximately the same, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the at least two sections of the intensity distribution.

16. The apparatus according to claim 15 , wherein the particular direction is approximately a vertical direction.

17. The apparatus according to claim 15 , wherein the second arrangement includes a plurality of lenses.

18. The apparatus according to claim 15 , wherein one of the sections is at least partially above another one of the sections.

19. The apparatus according to claim 15 , wherein the intensity distribution having a transverse resolution of a full width at half maximum is less than 10 μm.

20. The apparatus according to claim 15 , wherein at least a portion of the intensity distribution includes a non-Gaussian distribution.

21. The apparatus according to claim 20 , wherein a translation of the at least one of the intensity distribution or the sample produces an image which has 2 or more dimensions.

22. The apparatus according to claim 15 , further comprising a third arrangement adapted to cooperate with the second arrangement so as to translate at least one of the intensity distribution and the sample.

23. A method for imaging at least a portion of a sample, comprising:

a) providing an electro-magnetic radiation using an interferometric arrangement;

b) receiving the electro-magnetic radiation and generating a resultant electro-magnetic intensity distribution, wherein, along a particular direction, the intensity distribution is approximately constant for at least a predetermined distance, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the predetermined distance at which the intensity distribution is approximately constant.

24. The method according to claim 23 , wherein step (b) is performed using an optical arrangement which is configured to optically image the sample.

25. The method according to claim 23 , wherein step (b) is performed using an axicon lens.

26. The method according to claim 23 , wherein step (b) is performed using a defractive optical element.

27. The method according to claim 23 , wherein step (b) is performed using an annulus.

28. The method according to claim 23 , wherein step (b) is performed using a combination of a diffractive element and a lens.

29. The method according to claim 23 , wherein step (b) is performed using at least one of an apodized lens or a diffractive element.

30. The method according to claim 23 , wherein the intensity distribution is a Bessel beam.

31. The method according to claim 23 , further comprising translating at least one of the intensity distribution and the sample.

32. The method according to claim 31 , wherein the translation of the at least one of the intensity distribution and the sample produces an image which has 2 or more dimensions.

33. The method according to claim 23 , wherein the intensity distribution having a transverse resolution of a full width at half maximum is less than 10 μm.

34. The method according to claim 23 , wherein the predetermined distance is at least 50 μm.

35. The method according to claim 23 , wherein at least a portion of the intensity distribution includes a non-Gaussian distribution.

36. The method according to claim 23 , further comprising the steps of receiving information that is associated with the intensity distribution; and displaying an image based on the received information.

37. A method for imaging at least a portion of a sample, comprising:

providing an electro-magnetic radiation using an interferometric arrangement; and

receiving the electro-magnetic radiation, and generating a resultant electro-magnetic intensity distribution, wherein, along a particular direction, widths of at least two sections of the intensity distribution are approximately the same, and wherein a wavelength of the electro-macinetic radiation remains approximately the same for at least the at least two sections of the intensity distribution.

38. The method according to claim 37 , wherein step (b) is performed using an optical arrangement which is configured to optically image the sample.

39. The method according to claim 37 , wherein step (b) is performed using an axicon lens.

40. The method according to claim 37 , wherein step (b) is performed using a defractive optical element.

41. The method according to claim 37 , wherein step (b) is performed using an annulus.

42. The method according to claim 37 , wherein step (b) is performed using a combination of a diffractive element and a lens.

43. The method according to claim 37 , wherein step (b) is performed using at least one of an apodized lens or a diffractive element.

44. The method according to claim 37 , wherein the intensity distribution is a Bessel beam.

45. The method according to claim 37 , further comprising translating at least one of the intensity distribution and the sample.

46. The method according to claim 37 , wherein the translation of the at least one of the intensity distribution and the sample produces an image which has 2 or more dimensions.

47. The method according to claim 37 , wherein the intensity distribution having a transverse resolution of a full width at half maximum is less than 10 μm.

48. The method according to claim 37 , wherein the predetermined distance is at least 50 μm.

49. The method according to claim 37 , wherein at least a portion of the intensity distribution includes a non-Gaussian distribution.

50. The method according to claim 37 , further comprising the steps of receiving information that is associated with the intensity distribution; and displaying an image based on the received information.

51. An apparatus for imaging at least a portion of a sample, comprising:

a first interferometric arrangement providing an electro-magnetic radiation; and

a second arrangement provided within the first interferometric arrangement and configured to receive the electro-magnetic radiation, and configured to generate a resultant electro-magnetic intensity distribution,

wherein the second arrangement including a third arrangement which is configured to at least partially block at least one first portion of the electro-magnetic radiation, the third arrangement allowing at least one second portion of the electro-magnetic radiation to be provided in a center of the electro-magnetic radiation to pass there through.

52. The apparatus according to claim 51 , wherein the third arrangement is a masking arrangement which includes a section in a center thereof which allows the at least one second portion to pass there through.

53. An apparatus for imaging at least a portion of a sample, comprising:

a first interferometric arrangement providing an electro-magnetic radiation; and

a second arrangement configured to receive the electro-magnetic radiation, and configured to generate a resultant electro-magnetic intensity distribution,

wherein, along a particular direction, a plurality of focal points of the intensity distribution are generated, and

wherein a wavelength of the electro-magnetic radiation remains approximately the same along the particular direction for the focal points.

54. The apparatus according to claim 53 , wherein, along a particular direction, the intensity distribution is approximately constant for at least a predetermined distance.

55. The apparatus according to claim 53 , wherein the second arrangement includes a plurality of transceiver channels.

56. The apparatus according to claim 55 , wherein each of the channels is situated in an individual waveguide.

57. The apparatus according to claim 56 , wherein at least one of the waveguides is a optical fiber.

58. The apparatus according to claim 56 , wherein the second arrangement includes a plurality of lens, each of the lens being in an optical communication with a separate one of the waveguides.

59. A method for imaging at least a portion of a sample, comprising:

a) providing an electro-magnetic radiation using an interferometric arrangement;

b) at a further arrangement that is provided within the first interferometric arrangement, receiving the electro-magnetic radiation and generating a resultant electro-magnetic intensity distribution, wherein at least one first portion of the electro-magnetic radiation is at least partially blocked by a particular arrangement, and wherein at least one second portion of the electro-magnetic radiation provided in a center of the electro-magnetic radiation is allowed to pass through the particular arrangement.

60. A method for imaging at least a portion of a sample, comprising:

providing an electro-magnetic radiation using an interferometric arrangement; and

receiving the electro-magnetic radiation, and generating a resultant electro-magnetic intensity distribution, wherein, along a particular direction, a plurality of focal points of the intensity distribution are generated, and wherein a wavelength of the electro-magnetic radiation remains approximately the same along the particular direction for the focal points.

Assignments (2)
CONFIRMATORY LICENSE Recorded Aug 12, 2009
From: THE GENERAL HOSPITAL CORPORATION
To: US GOVERNMENT - SECRETARY FOR THE ARMY
Reel/Frame 023090/0156 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2004
From: TEARNEY, GUILLERMO J.; BOUMA, BRETT E.
To: THE GENERAL HOSPITAL CORPORATION
Reel/Frame 015994/0774 →
Continuity (2)
Provisional Application 6034752800 · Jan 11, 2002
Related Publication 20050018200A1 · Jan 27, 2005