Compounds

1. The compound which is:

8-(2,4,6-trifluorophenyl)-4-(2,4-difluorophenyl)-2-(2-hydroxy-1-hydroxymethylethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one;

4,8-Bis-(2,4-difluoro-phenyl)-2-(2-hydroxy-1-hydroxymethylethylamino)-8H-pyrido-[2,3-d]-pyrimidin-7-one;

8-(2,4,6-trifluorophenyl)-4-(2-fluorophenyl)-2-(2-hydroxy-1-hydroxymethylethylamino) -8H-pyrido[2,3-d]pyrimidin-7-one;

8-(2,4,6-trifluorophenyl)-4-(4-fluorophenyl)-2-(2-hydroxy-1-hydroxymethylethylamino) -8H-pyrido[2,3-d]pyrimidin-7-one;

4-(2-fluoro-phenyl)-8-(2,4-difluoro-phenyl)-2-((S)-2-hydroxy-1-methyl-ethylamino)-8H-pyrido-[2,3-d]-pyrimidin-7-one;

4-(2,4-Difluoro-phenyl)-8-(4-fluoro-phenyl)-2-((S)-2-hydroxy-1-methyl-ethylamino)-8H-pyrido-[2,3-d]-pyrimidin-7-one;

4,8-Bis-(2,4-difluoro-phenyl)-2-(2-hydroxy-1-methyl-ethylamino)-8H-pyrido-[2,3-d]-pyrimidin-7-one;

8-(2,4-Difluorophenyl)-4-(2-chloro-4-fluorophenyl)-2-(2-hydroxy-1-hydroxymethylethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one; or

8-(2,3-difluorophenyl)-4-(2,4-difluorophenyl)-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7- one; or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier or diluent.

3. The compound which is:

4-(2,4-difluoro-phenylamino)-6-(2,4,6-trifluorophenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde;

4-(2,4-difluoro-phenyl)-6-(2,4-difluorophenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde;

4-(2-fluorophenyl)-6-(2,4,6-trifluorophenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde;

4-(4-fluorophenyl)-6-(2,4,6-trifluorophenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde;

4-(2-fluorophenyl)-6-(2,4-difluorophenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde;

4-(2-chloro-4-fluorophenyl)-6-(2,4-difluorophenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde; or

4-(2,4-difluorophenyl)-6-(2,3-difluorophenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde.

4. The compound which is:

8-(2,4,6-trifluorophenyl)-4-(2,4-difluorophenyl)-2-(2-hydroxy-1-hydroxymethylethylamino)-8H-pyridio[2,3]pyrimidin-7-one; or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition comprising a compound according to claim 4 and a pharmaceutically acceptable carrier or diluent.

6. The compound which is:

8-(2,4,6-trifluorophenyl)-4-(2,4-difluorophenyl)-2-(2-hydroxy-1-hydroxymethylethylamino)-8H-pyridio[2,3]pyrimidin-7-one.

7. A pharmaceutical composition comprising a compound according to claim 6 and a pharmaceutically acceptable carrier or diluent.