Indole derivatives and drugs containing the same
An indole derivative represented by the following general formula (1): wherein at least one of R 1 , R 2 , R 3 , and R 4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R 1 , R 2 , R 3 , and R 4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH 2 ) n OH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component, wherein the indole derivative (1) has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.
1. An indole compound represented by the following formula (1):
wherein one of R 1 , R 2 , R 3 , and R 4 represents an alkoxy group of 1 to 20 carbon atoms, and other groups of the R 1 , R 2 , R 3 , and R 4 represent hydrogen or an alkyl group of 1 to 6 carbon atoms; and either one of X and Y represents —(CH 2 ) n OH wherein n is an integer of 10 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof.
2. The indole compound or its salt according to claim 1 wherein one of R 1 , R 2 , R 3 , an R 4 is an alkoxy group of 1 to 10 carbon atoms; and other groups of the R 1 , R 2 , R 3 , and R 4 are hydrogen; and n is 10 to 20.
3. A pharmaceutical composition comprising the indole compound or its salt of claim 1 and a pharmaceutically acceptable carrier.
4. A process for producing the pharmaceutical composition of claim 3 , comprising combining said indole compound and said pharmaceutically acceptable carrier.
5. The indole compound or its salt according to claim 1 wherein R 1 represents an alkoxy group; R 2 , R 3 , and R 4 represent hydrogen; and X represents —(CH 2 ) n OH.
6. The indole compound or its salt according to claim 1 wherein R 2 represents an alkoxy group; R 1 , R 3 , and R 4 represent hydrogen; and X represents —(CH 2 ) n OH.
7. The indole compound or its salt according to claim 1 wherein R 3 , represents an alkoxy group; R 1 , R 2 , and R 4 represent hydrogen; and X represents —(CH 2 ) n OH.
8. The indole compound or its salt according to claim 1 wherein R 4 represents an alkoxy group; R 1 , R 2 , and R 3 represent hydrogen; and X represents —(CH 2 ) n OH.
9. The indole compound or its salt according to claim 1 wherein R 1 represents an alkoxy group; R 2 , R 3 , and R 4 represent hydrogen; and Y represents —(CH 2 ) n OH.
10. The indole compound or its salt according to claim 1 wherein R 2 represents an alkoxy group; R 1 , R 3 , and R 4 represent hydrogen; and Y represents —(CH 2 ) n OH.
11. The indole compound or its salt according to claim 1 wherein R 3 , represents an alkoxy group; R 1 , R 2 , and R 4 represent hydrogen; and Y represents —(CH 2 ) n OH.
12. The indole compound or its salt according to claim 1 wherein R 4 represents an alkoxy group; R 1 , R 2 , and R 3 represent hydrogen; and Y represents —(CH 2 ) n OH.
13. The indole compound or its salt according to claim 1 wherein n is at least 14.
14. An indole compound represented by the following formula (1):
wherein at least one of R 1 , R 2 , R 3 , and R 4 represents an alkoxy group of 1 to 20 carbon atoms, and other groups of the R 1 , R 2 , R 3 , and R 4 represent hydrogen, an alkyl group of 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH 2 ) n OH wherein n is an integer of 10 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof.
15. An indole compound represented by the following formula (1):
wherein at least one of R 1 , R 2 , R 3 , and R 4 represents an alkoxy group of 1 to 20 carbon atoms, and other groups of the R 1 , R 2 , R 3 , and R 4 represent hydrogen or an alkyl group of 1 to 6 carbon atoms; and either one of X and Y represents —(CH 2 ) n OH wherein n is an integer of 10 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof.