Tyrosine kinase inhibitors

1. A compound as illustrated by Formula II:

wherein:

----- represents an optional double bond;

X is C, N, S(O) m or O;

G is H 2 or O;

R a is independently selected from:

1) H,

2) C 1 -C 6 alkyl,

3) Halogen,

4) Aryl,

5) Heterocycle,

6) C 3 -C 10 cycloalkyl, and

7) OR 4 ;

said alkyl, aryl, heterocycle and cycloalkyl is optionally substituted with at least one substituent selected from R 7 ;

R 1 is independently selected from:

(CR a 2 ) n R 6 ,

(CR a 2 ) n C(O)R 4 ,

C(O)N(R 4 ) 2 ,

(CR a 2 ) n OR 4 ,

(CR a 2 ) n N(R 4 ) 2 ,

S(O) m R 6 ,

S(O) m R 6 OR 4 ,

C(O)N(R 4 )(CR a 2 ) n R 6 ,

C(O)N(R 4 )(CR a 2 ) n OR 4 ,

C(O)R 6 (CR a 2 ) n R 6 ,

C(O)N(R 4 )(CR a 2 ) n S(O) m (CR a 2 ) n R 6 ,

C(O)N(R 4 )(CR a 2 ) n C(O)R 6 ,

C(O)N(R 4 )(CR a 2 ) n N(R 4 ) 2 ,

Halogen,

N(R 4 )S(O) m R 6 , and

(CR a 2 ) n C(O)OR 4 ;

R 2 is: NH 2 ;

R 4 independently selected from:

1) H,

2) C 1 -C 6 alkyl,

3) C 3 -C 10 cycloalkyl,

4) Aryl,

5) Heterocycle,

6) CF 3 ,

7) C 2 -C 6 alkenyl, and

8) C 2 -C 6 alkynyl;

said alkyl, cycloalkyl, aryl, heterocycle, alkenyl and alkynyl is optionally substituted with at least one substituent selected from R 7 ;

R 5 is independently selected from:

1) H,

2) Halogen,

3) NO 2 ,

4) CN,

5) CR 4 ═C(R 4 ) 2 ,

6) C≡CR 4 ,

7) (CR a 2 ) n OR 4 ,

8) (CR a 2 ) n N(R 4 ) 2 ,

9) C(O)R 4 ,

10) C(O)OR 4 ,

11) (CR a 2 ) n R 4 ,

12) S(O) m R 6 ,

13) S(O) m N(R 4 ) 2 ,

14) OS(O) m R 6 ,

15) N(R 4 )C(O)R 4 ,

16) N(R 4 )S(O) m R 6 ,

17) (CR a 2 ) n N(R 4 )R 6 ,

18) (CR a 2 ) n N(R 4 )R 6 OR 4 ,

19) (CR a 2 ) n N(R 4 )(CR a 2 ) n C(O)N(R 4 ) 2 ,

20) N(R 4 )(CR a 2 ) n R 6 ,

21) N(R 4 )(CR a 2 ) n N(R 4 ) 2 , and

22) (CR a 2 ) n C(O)N(R 4 ) 2 ;

R 6 is independently selected from:

1) C 1 -C 6 alkyl,

2) Aryl,

3) Heterocycle, and

4) C 3 -C 10 cycloalkyl;

said alkyl, aryl, heterocycle and cycloalkyl is optionally substituted with at least one substituent of R 7 ;

R 7 is independently selected from:

1) Unsubstituted or substituted C 1 -C 6 alkyl,

2) Halogen,

3) OR 4 ,

4) CF 3 ,

5) Unsubtituted or substituted aryl,

6) Unsubstituted or substituted C 3 -C 10 cycloalkyl,

7) Unsubstituted or substituted heterocycle,

8) S(O) m N(R 4 ) 2 ,

9) C(O)OR 4 ,

10) C(O)R 4 ,

11) CN,

12) C(O)N(R 4 ) 2 ,

13) N(R 4 )C(O)R 4 ,

14) S(O) m R 6 , and

15) NO 2 ;

m is independently 0,1 or 2;

n is independently 0, 1, 2, 3, 4, 5 or 6;

s is 0 to 6;

t is 0, 1, or 2;

v is 0, 1 or 2;

w is 0, 1, 2, 3, or 4;

or a pharmaceutically acceptable salt or stereoisomer thereof.

2. The compound according to claim 1 wherein:

R a is independently selected from:

1) H,

2) C 1 -C 6 alkyl,

3) Aryl, and

4) C 3 -C 10 cycloalkyl;

said alkyl, aryl, and cycloalkyl is optionally substituted with at least one substituent selected from R 7 ;

R 1 is independently selected from:

(CR a 2 ) n R 6 ,

(CR a 2 ) n C(O)R 4 ,

C(O)N(R 4 ) 2 ,

(CR a 2 ) n OR 4 ,

(CR a 2 ) n N(R 4 ) 2 ,

S(O) m R 6 ,

S(O) m R 6 OR 4 ,

C(O)N(R 4 )(CR a 2 ) n R 6 ,

C(O)N(R 4 )(CR a 2 ) n OR 4 ,

N(R 4 )S(O) m R 6 ,

(CR a 2 ) n C(O)OR 4 , and

R 6 C(O)OR;

R 2 is: NH 2 ;

s is 0 to 3;

or a pharmaceutically acceptable salt or stereoisomer thereof.

3. The compound according to claim 2 wherein:

R 1 is independently selected from:

(CR a 2 ) n R 6 ,

(CR a 2 ) n C(O)R 4 ,

C(O)N(R 4 ) 2 ,

(CR a 2 ) n OR 4 ,

(CR a 2 ) n N(R 4 ) 2 ,

S(O) m R 6 , and

S(O) m R 6 OR 4 ;

or a pharmaceutically acceptable salt or stereoisomer thereof.

4. A compound selected from:

5-Chloro-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Iodo-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Methoxy-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

6-Methoxy-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-(Methylsulfonyl)-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

7-Amino-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-nitro-1H-indole-2-carboxamide;

5-Chloro-3-(piperazin-1-ylsulfonyl)-1H-indole-2-carboxamide;

3-[(4-Benzylpiperazin-1-yl)sulfonyl]-5-chloro-1H-indole-2-carboxamide;

3-[(4-Acetylpiperazin-1-yl)sulfonyl]-5-chloro-1H-indole-2-carboxamide;

5-Chloro-3-(piperidin-1-ylsulfonyl)-1H-indole-2-carboxamide;

5-Chloro-3-(pyrrolidin-1-ylsulfonyl)-1H-indole-2-carboxamide;

5-Chloro-3-(thiomorpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Azetidin-1-ylsulfonyl)-5-chloro-1H-indole-2-carboxamide;

5-Chloro-3-[(oxidothiomorpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Chloro-3-[(1,1-dioxidothiomorpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

cis-5-Chloro-3-(2,6-dimethylmorpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

trans-5-Chloro-3-(2,6-dimethylmorpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Chloro-3-[(3-hydroxyazetidin-1-yl)sulfonyl]-1H-indole-2-carboxamide;

(±)-5-Chloro-3-{[2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

(S)-5-Chloro-3-{[2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

(R)-5-Chloro-3-{[2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-({4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepan-1-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-({5-oxo-1,4-diazepan-1-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-[(3-oxopiperazin-1-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(3-hydroxyazetidin-1-yl)sulfonyl]-1H-indole-2-carboxamide;

(±)-5-Bromo-3-{[2-(aminocarbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

3-(Azetidin-1-ylsulfonyl)-5-bromo-1H-indole-2-carboxamide;

5-Bromo-3-({4-[(4-methoxyphenyl)sulfonyl]piperazin-1-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-({4-[(4-bromophenyl)sulfonyl]piperazin-1-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-{[4-(3-morpholin-4-ylpropyl)-3-oxopiperazin-1-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-({4-[3-(dimethylamino)propyl]-3-oxopiperazin-1-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-(2,5-dihydroxy-1H-pyrrol-1-ylsulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-(6-oxa-3-azabicyclo[3.1.0]hex-3-ylsulfonyl)-1H-indole-2-carboxamide;

(±)-5-Bromo-3-{[2-(phenoxymethyl)morpholino-4-yl]sulfonyl}-1H-indole-2-carboxamide;

(S)-5-Bromo-3-{[2-(phenoxymethyl)morpholino-4-yl]sulfonyl}-1H-indole-2-carboxamide;

(R)-5-Bromo-3-{[2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

6-Hydroxy-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-(2-Furyl)-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-(phenylethynyl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-(2-phenylethyl)-1H-indole-2-carboxamide;

5-Hex-1-ynyl-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Hexyl-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

Methyl 2-(aminocarbonyl)-3-(morpholin-4-ylsulfonyl)-1H-indole-5-carboxylate;

3-(Morpholin-4-ylsulfonyl)-5-vinyl-1H-indole-2-carboxamide;

5-Hydroxy-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Ethoxy-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-propoxy-1H-indole-2-carboxamide;

5-Isopropoxy-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Ethyl-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

2-(Aminocarbonyl)-3-(morpholin-4-ylsulfonyl)-1H-indol-5-yl methanesulfonate;

3-(Morpholin-4-ylsulfonyl)-5-prop-1-ynyl-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-thien-2-yl-1H-indole-2-carboxamide;

3-(Azetidin-1-ylsulfonyl)-5-methoxy-1H-indole-2-carboxamide;

5-Formyl-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Methyl-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

7-(Acetylamino)-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

7-[(Methylsulfonyl)amino]-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-{[(4-Methoxyphenyl)amino]methyl}-3-morpholino-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-{[(2-Acetamide)amino]methyl}-3-morpholino-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Morpholino-4-ylsulfonyl)-5-phenyl-1H-indole-2-carboxamide;

3-(Morpholino-4-ylsulfonyl)-5-pyrazin-2-yl-1H-indole-2-carboxamide;

3-(Morpholino-4-ylsulfonyl)-5-pyridin-2-yl-1H-indole-2-carboxamide;

3-(Morpholino-4-ylsulfonyl)-5-pyridin-4-yl-1H-indole-2-carboxamide;

5-(1-Benzofuran-2-yl)-3-(morpholino-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-(5-Methyl-2-furyl)-3-(morpholino-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-(3,5-Dimethylisoxazole-4-yl)-3-(morpholino-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-(1H-pyrrol-2-yl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-pyridin-3-yl-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-(1,3-thiazol-2-yl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-thien-3-yl-1H-indole-2-carboxamide;

5-(1-Benzothien-3-yl)-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Azetidin-1-yl}sulfonyl)-5-iodo-1H-indole-2-carboxamide;

3-[(3-Hydroxyazetidin-1-yl)sulfonyl]-5-iodo-1H-indole-2-carboxamide;

(±)-5-Iodo-3-{[2-(phenoxymethyl)morpholino-4-yl]sulfonyl}-1H-indole-2-carboxamide;

(S)-5-Iodo-3-{[2-(phenoxymethyl)morpholino-4-yl]sulfonyl}-1H-indole-2-carboxamide;

(R)-5-Iodo-3-{[2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

7-Amino-6-bromo-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

7-Amino-4,6-dibromo-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

6-Bromo-7-(dimethylamino)-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-7-[(pyridin-4-ylmethyl)amino]-1H-indole-2-carboxamide;

7-{[(2-Chloropyridin-4-yl)methyl]amino}-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

7-Nitro-3-{[(2S)-2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

7-Amino-3-{[(2S)-2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

3-{[(2S)-2-(Phenoxymethyl)morpholin-4-yl]sulfonyl}-7-[(pyridin-4-ylmethyl)amino]-1H-indole-2-carboxamide;

7-(Benzylamino)-3-{[(2S)-2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

7-Chloro-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

6-Bromo-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

7-Bromo-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

7-Cyano-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

(±)-7-(Methylsulfinyl)-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

7-Aminomethyl-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Amino-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

(S)-5-Fluoro-3-{[2-(phenoxymethyl)morpholino-4-yl]sulfonyl}-1H-indole-2-carboxamide;

(R)-5-Fluoro-3-{[2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Acetylamino-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-[(Methylsulfonyl)amino]-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

3-(Morpholin-4-ylsulfonyl)-5-[(trifluoroacetyl)amino]-1H-indole-2-carboxamide;

5-[(2-Aminoethyl)amino]-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-(Dimethylamino)-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

4,5-Dibromo-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5,6-Dibromo-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Bromo-4-nitro-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Bromo-6-nitro-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Bromo-6-amino-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

5-Bromo-4-amino-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide;

(S)-3-{[2-(Phenoxymethyl)morpholino-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(cyclohexylamino)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(2,3-dihydro-1H-inden-1-ylamino)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-phenylethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(3-phenylpropyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(3,3-diphenylpropyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-{[2-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-phenoxyethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

3-({2-[(3-Benzylpyrrolidin-1-yl)carbonyl]morpholin-4-yl}sulfonyl)-5-bromo-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(1,2,3,4-tetrahydronaphthalen-2-ylmethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

3-({2-[(Benzylamino)carbonyl]morpholin-4-yl}sulfonyl)-5-bromo-1H-indole-2-carboxamide;

5-Bromo-3-{[2-({[3-(trifluoromethyl)benzyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2,2-diphenylethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(2,3-dihydro-1H-inden-2-ylamino)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

7-{[2-(Aminocarbonyl)-5-bromo-1H-indol-3-yl]sulfonyl}-2-benzyl-7-aza-2-azoniaspiro[4.4]nonane;

5-Bromo-3-{[2-({[(5-methylpyrazin-2-yl)methyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

3-({[(4-{[2-(Aminocarbonyl)-5-bromo-1H-indol-3-yl]sulfonyl}morpholin-2-yl)carbonyl]amino}methyl)pyridine;

5-Bromo-3-[(2-{[(1-phenylethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

1-(3-{[(4-{[2-(Aminocarbonyl)-5-bromo-1H-indol-3-yl]sulfonyl}morpholin-2-yl)carbonyl]amino}propyl)-1H-imidazole;

5-Bromo-3-{[2-({[(1R)-1-phenylethyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-phenylpropyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

3-[(2-{[Benzyl(methyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-5-bromo-1H-indole-2-carboxamide;

1-[(4-{[2-(Aminocarbonyl)-5-bromo-1H-indol-3-yl]sulfonyl}morpholin-2-yl)carbonyl]-4-benzylpiperazine;

2-({[(4-{[2-(Aminocarbonyl)-5-bromo-1H-indol-3-yl]sulfonyl}morpholin-2-yl)carbonyl]amino}methyl)pyridine;

5-Bromo-3-{[2-({[2-(tert-butylthio)ethyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

3-({2-[(Benzhydrylamino)carbonyl]morpholin-4-yl}sulfonyl)-5-bromo-1H-indole-2-carboxamide;

5-Bromo-3-{[2-({[(2S)-2-phenylcyclopropyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(3-phenylpyrrolidin-1-yl)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(4,4-diphenylpiperidin-1-yl)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2,3-dihydro-1H-inden-2-ylmethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(2,3-dihydro-1H-inden-1-ylamino)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(2,3-dihydro-1H-inden-1-ylamino)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(3-pyridin-4-ylpyrrolidin-1-yl)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-hydroxy-2,3-dihydro-1H-inden-1-yl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(4-hydroxy-4-phenylpiperidin-1-yl)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

3-{[2-(Anilinocarbonyl)morpholin-4-yl]sulfonyl}-5-bromo-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-oxo-2-phenylethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-({2-[(neopentylamino)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(1,2-diphenylethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(4-chlorophenyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(4-phenoxyphenyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(4-tert-butylphenyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-{[2-({[3-(2-oxopyrrolidin-1-yl)propyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(3-isopropoxypropyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(3-ethoxypropyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-cyclohex-1-en-1-ylethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2,2,3,3,4,4,4-heptafluorobutyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(3-isobutoxypropyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(3-butoxypropyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-thien-2-ylethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

2-({[(4-{[2-(Aminocarbonyl)-5-bromo-1H-indol-3-yl]sulfonyl}morpholin-2-yl)carbonyl]amino}methyl)-1H-benzimidazole;

3-{[2-(Azepan-1-ylcarbonyl)morpholin-4-yl]sulfonyl}-5-bromo-1H-indole-2-carboxamide;

5-Bromo-3-({2-[({2-[(2,6-dichlorobenzyl)thio]ethyl}amino)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

3-{[2-({[4-(Aminosulfonyl)benzyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-5-bromo-1H-indole-2-carboxamide;

5-Bromo-3-{[2-(thiomorpholin-4-ylcarbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-methoxyethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-methoxy-1-methylethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(1-ethylpropyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-{[2-({[6-(dimethylamino)hexyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(tetrahydrofuran-2-ylmethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(1-phenylcyclopropyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-{[2-({[phenyl(pyridin-4-yl)methyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(dicyclopropylmethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(1,4-dioxan-2-ylmethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-{[2-({methyl[2-(4-methylphenoxy)ethyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-{[2-({[(1,1-dioxidotetrahydrothien-3-yl)methyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[2-(2-phenylethyl)pyrrolidin-1-yl]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(2-cyclohexylethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

4-({[(4-{[2-(Aminocarbonyl)-5-bromo-1H-indol-3-yl]sulfonyl}morpholin-2-yl)carbonyl]amino}methyl)-1-methyl-1H-imidazole;

5-Bromo-3-[(2-{[(1,1-dioxidotetrahydrothien-3-yl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(1-naphthylmethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

5-Bromo-3-[(2-{[(imidazo[2,1-b][1,3]thiazol-6-ylmethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide;

3-[(2-{[2-(1,3-Benzothiazol-2-yl)pyrrolidin-1-yl]carbonyl}morpholin-4-yl)sulfonyl]-5-bromo-1H-indole-2-carboxamide;

5-Chloro-3-({2-[(2-ethoxyphenoxy)methyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

5-Chloro-3-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylsulfonyl]-1H-indole-2-carboxamide;

7-{[2-(Aminocarbonyl)-5-chloro-1H-indol-3-yl]sulfonyl}-3-benzyl-9-thia-7-aza-3-azoniabicyclo[3.3.1]nonane;

5-Chloro-3-{[2-(1H-indol-4-yl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Chloro-3-(2,3-dihydro-1,4-benzoxazepin-4(5H)-ylsulfonyl)-1H-indole-2-carboxamide;

3-[(Benzofuran-yl-1-oxa-8-azaspiro[4.5]dec-8-yl)sulfonyl]-5-chloro-1H-indole-2-carboxamide;

5-Chloro-3-{[4-fluoro-4-(3-phenylpropyl)piperidin-1-yl]sulfonyl}-1H-indole-2-carboxamide;

3-[(3-Benzyl-1-oxa-8-azaspiro[4.5]dec-8-yl)sulfonyl]-5-chloro-1H-indole-2-carboxamide;

3-({4-[(Benzyloxy)methyl]-4-phenylpiperidin-1-yl}sulfonyl)-5-chloro-1H-indole-2-carboxamide;

5-Chloro-3-{[4-hydroxy-4-(3-phenylpropyl)piperidin-1-yl]sulfonyl}-1H-indole-2-carboxamide;

7-{[2-(Aminocarbonyl)-5-chloro-1H-indol-3-yl]sulfonyl}-2-(4-chlorophenyl)-7-aza-2-azoniaspiro[4.4]nonane;

3-(1-{[2-(Aminocarbonyl)-5-chloro-1H-indol-3-yl]sulfonyl}piperidin-3-yl)-4-methyl-4H-1,2,4-triazole;

5-Chloro-3-{[3-(2-phenylethyl)piperidin-1-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Chloro-3-{[3-(2-phenylethyl)pyrrolidin-1-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Chloro-3-{[4-(cyclopropyl{[3-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Chloro-3-({2-[(4-chlorophenoxy)methyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide;

Tert-butyl(1-{[2-(aminocarbonyl)-5-chloro-1H-indol-3-yl]sulfonyl}piperidin-3-yl)acetate;

3-[(3-Benzylpiperidin-1-yl)sulfonyl]-5-chloro-1H-indole-2-carboxamide;

5-Chloro-3-{[3-(2-methylphenyl)piperidin-1-yl]sulfonyl}-1H-indole-2-carboxamide;

2-(1-{[2-(Aminocarbonyl)-5-chloro-1H-indol-3-yl]sulfonyl}piperidin-4-yl)-N,N-dimethylethanamine;

1-(1-{[2-(Aminocarbonyl)-5-chloro-1H-indol-3-yl]sulfonyl}piperidin-4-yl)-3-(ethoxycarbonyl)piperidine;

5-Bromo-3-{[3-(4-tert-butoxybenzyl)piperidin-1-yl]sulfonyl}-1H-indole-2-carboxamide;

5-Bromo-3-{[4-(3-phenylpropyl)piperidin-1-yl]sulfonyl}-1H-indole-2-carboxamide; and

5-Bromo-N-methoxy-N-methyl-3-{[2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide;

or a pharmaceutically acceptable salt or stereoisomer thereof.

5. The compound according claim 4 that is selected

3-(Morpholin-4-ylsulfonyl)-5-(1,3-thiazol-2-yl)-1H-indole-2-carboxamide

(S)-5-Iodo-3-{[2-(phenoxymethyl)morpholino-4-yl]sulfonyl}-1H-indole-2-carboxamide

5-Bromo-6-amino-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxamide

5-bromo-3-({2-[(2,3-dihydro-1H-inden-2-ylamino)carbonyl]morpholin-4-yl}sulfonyl)-1H-indole-2-carboxamide

5-bromo-3-{[2-({[2-(tert-butylthio)ethyl]amino}carbonyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide

5-bromo-3-[(2-{[(1-naphthylmethyl)amino]carbonyl}morpholin-4-yl)sulfonyl]-1H-indole-2-carboxamide

or a pharmaceutically acceptable salt or stereoisomer thereof.

6. A pharmaceutical composition which is comprised of a compound in accordance with claim 1 and a pharmaceutically acceptable carrier.