Phospholipid derivative
View Patent ↗A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R 1 and R 2 represent hydrogen atom or methyl group, provided that R 1 and R 2 do not simultaneously represent methyl group; R 3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4≦m≦100; R 4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R 5 CO and R 6 CO represent an acyl group having 8 to 24 carbon atoms; R 7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium] wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.
1. A phospholipid derivative, which is a phospholipid and is a copolymer containing, as essential component units,
(A) a component unit A represented by the following formula (1),
(B) a component unit B represented by the following formula (2A) and/or the following formula (2B), and
(C) a component unit C represented by the following formula (3):
wherein, in the formula (1), R 1 and R 2 independently represent hydrogen atom or methyl group, provided that R 1 and R 2 do not simultaneously represent methyl group; R 3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO independently represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4≦m≦100; and R 4 represents hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms or an acyl group having 1 to 20 carbon atoms; in the formula (2A), X independently represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; and in the formula (3), R 5 CO and R 6 CO independently represent an acyl group having 8 to 24 carbon atoms; R 7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium, and Y represents hydrogen atom, an alkali metal atom ammonium or an organic ammonium, wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 5 moles per 1 mole of the copolymer.
2. The phospholipid derivative according to claim 1 , wherein the total number of the component unit(s) A, the component unit(s) B, and the component unit(s) C contained in the copolymer is 3 or more and 150 or less.
3. The phospholipid derivative according to claim 1 , wherein the total number of the component unit(s) A, the component unit(s) B, and the component unit(s) C contained in the copolymer is 5 or more and 50 or less.
4. The phospholipid derivative according to claim 1 , wherein R 1 is hydrogen atom, R 2 is hydrogen atom or methyl group, and R 3 is methylene group.
5. The phospholipid derivative according to claim 1 , wherein R 7 is ethylene group.
6. A surfactant comprising the phospholipid derivative according to claim 1 .
7. A lipid membrane structure comprising the phospholipid derivative according to claim 1 .
8. The lipid membrane structure according to claim 7 , which is a liposome.
9. A pharmaceutical composition containing the lipid membrane structure according to claim 7 retaining a medicament.
10. The pharmaceutical composition according to claim 9 , wherein the medicament is an antitumor agent.
11. A method for producing the phospholipid derivative according to claim 1 , which comprises the step of reacting a copolymer containing the component unit A and the component unit B at a molar ratio of from 7/3 to 3/7 with a compound represented by the following formula (4):
wherein R 5 CO, R 6 CO, R 7 , and Y have the same meanings as defined above.