Painless injectable compositions containing salts of 2-arylpropionic acids
The invention relates to pharmaceutical compositions of alkylammonium salts of 2-aryipropionic acids, including ketoprofen, ibuprofen, naproxen and tiaprofenic acid. The compositions are suitable for parenteral administration arid, due to buffering at pH 8 to 9, cause less pain upon injection than previously known composition.
1. A pharmaceutical composition having anti-inflammatory and analgesic property, comprising an alkylammonium salt of a 2-arylpropionic acid which is a L-lysine salt of ketoprofen in an aqueous solution at a pH in the range from 8 to 9, said solution being free of preservatives and co-solvents, wherein the composition is formulated for parenteral administration.
2. The pharmaceutical composition of claim 1 , further comprising sodium bicarbonate.
3. The pharmaceutical composition of claim 2 , wherein the concentration of said sodium carbonate is 4 mg/ml.
4. The pharmaceutical composition of claim 1 , further comprising sodium hydroxide.
5. The pharmaceutical composition of claim 4 , wherein the concentration of said sodium hydroxide is 1.5 mg/ml.