Narcistatin prodrugs
The present invention provides prodrugs derived from the sparingly soluble anticancer isocarbostyril narciclasine, a component of various Narcissus species, said prodrugs having potential for use against animal and human cancers. Also disclosed is an efficient procedure for the synthetic conversion of narciclasine to several more soluble cyclic phosphate compounds, including “narcistatin”.
1. A compound having the following structure:
wherein Z is selected from the group consisting of pyridinium, H + , Li + , Na + , K + , Cs + , Mg 2+ , Ca 2+ , Zn 2+ , Mn 2+ , quinidine, quinine, imidazole, morpholine and piperazine.
2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier therefore.
3. A method for treating cancer selected from the group consisting of leukemia, pancreatic cancer, breast cancer, central nervous system cancer, lung cancer, colon cancer and prostate cancer, comprising administering to a human subject afflicted with cancer a pharmaceutically effective amount of the compound:
wherein Z is selected from the group consisting of pyridinium, H + , Li + , Na 30 , K + , Cs + , Mg 2+ , Ca 2+ , Zn 2+ , Mn 2+ , quinidine, quinine, imidazole, morpholine and piperazine.