Compounds

1. A compound of the formula:

wherein

R 1 is an optionally substituted aryl or an optionally substituted heteroaryl ring;

X is R 2 , OR 2 , S(O) m R 2 , (CH 2 ) n N(R 10 )S(O) m R 2 , (CH 2 ) n N(R 10 )C(O)R 2 , (CH 2 ) n NR 4 R 14 , NR 2 (CH 2 ) n NR 4 R 14 , O(CH 2 ) n NR 4 R 14 , S(CH 2 ) n NR 4 R 14 , (CH 2 ) n J, NR 2 (CH 2 ) n J, O(CH 2 ) n J, S(CH 2 ) n J, or (CH 2 ) n N(R 2 ) 2 ;

J is an optionally substituted heteroaryl ring;

n is 0 or an integer having a value of 1 to 10;

m is 0 or an integer having a value of 1 or 2;

q is 0 or an integer having a value of 1 to 10;

R 2 is independently selected from a hydrogen, C 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl, or heteroarylC 1-10 alkyl moiety, which moieties, excluding hydrogen, are all optionally substituted; or R 2 is the moiety X 1 (CR 10 R 20 ) q C(A 1 )(A 2 )(A 3 ), or C(A 1 )(A 2 )(A 3 );

X 1 is N(R 10 ), O, S(O) m , or CR 10 R 20 ;

X 2 is independently hydrogen, halogen or C 1-4 alkyl;

A 1 is an optionally substituted C 1-10 alkyl;

A 2 is an optionally substituted C 1-10 alkyl;

A 3 is hydrogen or is an optionally substituted C 1-10 alkyl;

G 1 is C—X 2 ;

R 3 is C 1-10 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, aryl, arylC 1-10 alkyl, heteroaryl, heteroarylC 1-10 alkyl, heterocyclic, or a heterocyclylC 1-10 alkyl moiety, which moieties are optionally substituted;

R 4 and R 14 are each independently selected from hydrogen, optionally substituted C 1-4 alkyl, optionally substituted aryl, or optionally substituted aryl-C 1-4 alkyl, arylC 1-10 alkyl, heteroaryl or heteroarylC 1-10 alkyl, wherein each of these moieties may be optionally substituted;

R 10 and R 20 are independently selected from hydrogen or C 1-4 alkyl; or

a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 wherein R 1 is an optionally substituted phenyl or naphthyl.

3. The compound according to claim 2 wherein the phenyl is substituted one or more times independently by halogen, alkyl, hydroxy, alkoxy, amino, or halosubstituted alkyl.

4. The compound according to claim 3 wherein the substituents are independently chlorine, fluorine, C 1-4 alkyl, or CF 3 .

5. The compound according to claim 3 wherein the phenyl ring is substituted in the 2, 4, or 6-position, di-substituted in the 2,4-position, or tri-substituted in the 2,4,6-position.

6. The compound according to claim 1 wherein X is OR 2 , or S(O) m R 2 .

7. The compound according to claim 1 wherein X is (CH 2 ) n NR 4 R 14 , or (CH 2 ) n N(R 2 ) 2 .

8. The compound according to claim 1 wherein X is R 2 or (CH 2 ) n N(R 10 )S(O) m R 2 , or (CH 2 ) n N(R 10 )C(O)R 2 .

9. The compound according to claim 1 wherein R 2 , other than hydrogen, is optionally substituted independently one or more times with C 1-10 alkyl, halo-substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-10 alkyl, C 5-7 cycloalkenyl, C 5-7 cycloalkenyl C 1-10 alkyl, halogen, —C(O), cyano, nitro, (CR 10 R 20 ) n OR 6 , (CR 10 R 20 ) n SH, (CR 10 R 20 ) n S(O) m R 7 , (CR 10 R 20 ) n NR 10 S(O) 2 R 7 , (CR 10 R 20 ) n NR 4 R 14 , (CR 10 R 20 ) n CN, (CR 10 R 20 ) n S(O) 2 NR 4 R 14 , (CR 10 R 20 ) n C(Z)R 6 , (CR 10 R 20 ) n OC(Z)R 6 , (CR 10 R 20 ) n C(Z)OR 6 , (CR 10 R 20 ) n C(Z)NR 4 R 14 , (CR 10 R 20 ) n NR 10 C(Z)R 6 , (CR 10 R 20 ) n NR 10 C(═NR 10 )NR 4 R 14 , (CR 10 R 20 ) n C(═NOR 6 )NR 4 R 14 , (CR 10 R 20 ) n OC(Z)NR 4 R 14 , (CR 10 R 20 ) n NR 10 C(Z)NR 4 R 14 , or (CR 10 R 20 ) n NR 10 C(Z)OR 7 ;

and wherein

R 6 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, heterocyclyl, heterocyclyl C 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl or a heteroarylC 1-10 alkyl moiety, and wherein these moieties, excluding hydrogen, are optionally substituted;

R 7 is C 1-6 alkyl, aryl, arylC 1-6 alkyl, heterocyclic, heterocyclylC 1-16 alkyl, heteroaryl, or a heteroarylC 1-6 alkyl moiety; and wherein each of these moieties are optionally substituted; and

Z is oxygen or sulfur.

10. The compound according to claim 6 wherein R 2 is an optionally substituted C 1-10 alkyl.

11. The compound according to claim 10 wherein the alkyl is substituted by (CR 10 R 20 ) n C(Z)OR 6 , (CR 10 R 20 ) n OR 6 , or (CR 10 R 20 ) n NR 4 R 14 and R 6 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, heterocyclyl, heterocyclyl C 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl or a heteroarylC 1-10 alkyl moiety, and wherein the R 6 moieties, excluding hydrogen, are optionally substituted.

12. The compound according to claim 1 wherein R 2 is the X 1 (CR 10 R 20 ) q C(A 1 )(A 2 )(A 3 ), or C(A 1 )(A 2 )(A 3 ).

13. The compound according to claim 12 wherein X 1 is oxygen or N(R 10 ).

14. The compound according to claim 12 wherein at least one of A 1 , A 2 or A 3 is substituted by (CR 10 R 20 ) n OR 6 and R 6 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, heterocyclyl, heterocyclyl C 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl or a heteroarylC 1-10 alkyl moiety, and wherein the R 6 moieties, excluding hydrogen, are optionally substituted.

15. The compound according to claim 14 , wherein q is 0, 1 or 2.

16. The compound according to claim 1 wherein R 3 is an optionally substituted C 1-10 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, aryl, arylC 1-10 alkyl.

17. The compound according to claim 16 wherein R 3 is optionally substituted one or more times independently with C 1-10 alkyl, halo-substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-10 alkyl, C 5-7 cycloalkenyl, C 5-7 cycloalkenylC 1-10 alkyl, halogen, cyano, nitro, (CR 10 R 20 ) n OR 6 , (CR 10 R 20 ) n SH, (CR 10 R 20 ) n S(O) m R 7 , (CR 10 R 20 ) n NR 10 S(O) 2 R 7 , (CR 10 R 20 ) n NR 4 R 14 , (CR 10 R 20 ) n CN, (CR 10 R 20 ) n S(O) 2 NR 4 R 14 , (CR 10 R 20 ) n C(Z)R 6 , (CR 10 R 20 ) n OC(Z)R 6 , (CR 10 R 20 ) n C(Z)OR 6 , (CR 10 R 20 ) n C(Z)NR 4 R 14 , (CR 10 R 20 ) n NR 10 C(Z)R 6 , (CR 10 R 20 ) n NR 10 C(═NR 10 )NR 4 R 14 , (CR 10 R 20 ) n OC(Z)NR 4 R 14 , (CR 10 R 20 ) n NR 10 C(Z)NR 4 R 14 , or (CR 10 R 20 ) n NR 10 C(Z)OR 7 ;

and wherein

R 6 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, heterocyclyl, heterocyclyl C 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl or a heteroarylC 1-10 alkyl moiety, and wherein these moieties, excluding hydrogen, are optionally substituted;

R 7 is C 1-6 alkyl, aryl, arylC 1-6 alkyl, heterocyclic, heterocyclylC 1-6 alkyl, heteroaryl, or a heteroarylC 1-6 alkyl moiety; and wherein each of these moieties are optionally substituted.

18. The compound according to claim 17 wherein the optional substituent is halogen, C 1-10 alkyl, hydroxy, alkoxy, amino, or halosubstituted C 1-10 alkyl.

19. The compound according to claim 1 wherein X 2 is hydrogen.

20. The compound according to claim 1 , which is:

1,5-bis(4-fluorophenyl)[1,8]naphthyridin-2(1H)-one;

5-(2,4-difluorophenyl)-1-(4-fluorophenyl)[1,8]naphthyridin-2(1H)-one;

1,5-bis(2-chlorophenyl)-7-{[2-(isopropylamino)ethyl]amino}[1,8]naphthyridin-2(1H)-one;

1,5-bis(2-chlorophenyl)-7-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}[1,8]-naphthyridin-2(1H)-one;

or a pharmaceutically acceptable salt thereof.

21. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 and a pharmaceutically acceptable carrier or diluent.