Anti-viral activity of cathelicidin peptides
View Patent ↗The disclosure provides methods and compositions useful in the treatment of dermatitis and viral infections. The compositions comprise cationic peptides of the cathelicidin family including LL-37, related homologues, and variants thereof.
1. A purified cationic peptide consisting of a sequence as set forth in SEQ ID NO:3 that has an antiviral activity.
2. A method for inhibiting the spread and/or the risk of infection of a virus infection comprising contacting a virus with an inhibiting effective amount of a cationic antiviral peptide composition, the antiviral peptide consisting of SEQ ID NO:3, wherein the virus is selected from a pox virus, a herpes virus, vaccinia virus, and papilloma virus.
3. The method of claim 2 , wherein the contacting is in vitro.
4. The method of claim 3 , wherein the contacting is on a surface suspected of having viral particles.
5. The method of claim 2 , wherein the contacting is in vivo.
6. The method of claim 5 , wherein the contacting in vivo is by topical administration.
7. The purified cationic peptide of claim 1 , further comprising a pharmaceutically acceptable carrier.
8. The purified cationic peptide of claim 7 , wherein the pharmaceutical acceptable carrier is useful for formulating a lotion, cream, gel, ointment or spray.
9. The pharmaceutical composition of claim 7 , wherein the pharmaceutical compositions is for topical administration.